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Santhi Gorantla

Researcher at University of Nebraska Medical Center

Publications -  97
Citations -  5088

Santhi Gorantla is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Immune system & Virus. The author has an hindex of 36, co-authored 94 publications receiving 3998 citations. Previous affiliations of Santhi Gorantla include Colorado State University.

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Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.

TL;DR: It is demonstrated that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantia nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor.
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Mechanism of alcohol-induced oxidative stress and neuronal injury

TL;DR: Novel quantitative methods of ROS and NO detection help dissect the mechanisms of alcohol-induced neurodegeneration by uncovering the basic mechanisms of oxidative neuronal injury and will serve as the basis for development of new therapies.
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Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast.

TL;DR: The hypothesis that cerebral vascular injury occurs before the development of neurological disorders in mild TBI was confirmed by the activation of caspase-3 and cell apoptosis mostly around the perivascular region and induction of oxidative stress and activation of matrix metalloproteinases by shock wave underlie the mechanisms of cerebral vascular BBB leakage and neuroinflammation.