S
Santhi Gorantla
Researcher at University of Nebraska Medical Center
Publications - 97
Citations - 5088
Santhi Gorantla is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Immune system & Virus. The author has an hindex of 36, co-authored 94 publications receiving 3998 citations. Previous affiliations of Santhi Gorantla include Colorado State University.
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Journal ArticleDOI
Diagnostics for SARS-CoV-2 infections.
Bhavesh D. Kevadiya,Jatin Machhi,Jonathan Herskovitz,Maxim D. Oleynikov,Wilson R. Blomberg,Neha Bajwa,Dhruvkumar Soni,Srijanee Das,Mahmudul Hasan,Milankumar Patel,Ahmed M. Senan,Santhi Gorantla,JoEllyn M McMillan,Benson J Edagwa,Robert Eisenberg,Channabasavaiah B. Gurumurthy,St Patrick Reid,Chamindie Punyadeera,Linda Chang,Howard E. Gendelman +19 more
TL;DR: A review of available and in-development diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) including nanomaterial-based tools is presented in this paper.
Journal ArticleDOI
Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.
Eric J. Benner,R. Lee Mosley,Christopher J. Destache,Travis B. Lewis,Vernice Jackson-Lewis,Santhi Gorantla,Craig Nemachek,Steven R. Green,Serge Przedborski,Howard E. Gendelman +9 more
TL;DR: It is demonstrated that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantia nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor.
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Mechanism of alcohol-induced oxidative stress and neuronal injury
James Haorah,Servio H. Ramirez,Nicholas A. Floreani,Santhi Gorantla,Brenda Morsey,Yuri Persidsky +5 more
TL;DR: Novel quantitative methods of ROS and NO detection help dissect the mechanisms of alcohol-induced neurodegeneration by uncovering the basic mechanisms of oxidative neuronal injury and will serve as the basis for development of new therapies.
Journal ArticleDOI
Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast.
P. M. Abdul-Muneer,Heather Schuetz,Fang Wang,Maciej Skotak,Joselyn Jones,Santhi Gorantla,Matthew C. Zimmerman,Namas Chandra,James Haorah +8 more
TL;DR: The hypothesis that cerebral vascular injury occurs before the development of neurological disorders in mild TBI was confirmed by the activation of caspase-3 and cell apoptosis mostly around the perivascular region and induction of oxidative stress and activation of matrix metalloproteinases by shock wave underlie the mechanisms of cerebral vascular BBB leakage and neuroinflammation.
Journal ArticleDOI
Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery
Huanyu Dou,Christopher J. Destache,Christopher J. Destache,Christopher J. Destache,Justin R. Morehead,Justin R. Morehead,Justin R. Morehead,R. Lee Mosley,Michael D. Boska,Michael D. Boska,Michael D. Boska,Jeffrey Kingsley,Jeffrey Kingsley,Jeffrey Kingsley,Santhi Gorantla,Larisa Y. Poluektova,Jay A. Nelson,Jay A. Nelson,Jay A. Nelson,Mahesh Chaubal,Mahesh Chaubal,Mahesh Chaubal,Jane Werling,Jane Werling,Jane Werling,James E. Kipp,James E. Kipp,James E. Kipp,Barrett E. Rabinow,Barrett E. Rabinow,Barrett E. Rabinow,Howard E. Gendelman +31 more
TL;DR: It is concluded that a single dose of NP-IDV, using BMMs as a carrier, is effective and warrants consideration for human testing.