Santo Landolfo

TL;DR: Human cytomegalovirus (HCMV), a betaherpesvirus, represents the major infectious cause of birth defects, as well as an important pathogen for immunocompromised individuals and contributes to graft loss independently from graft rejection.

TL;DR: This work reviews the viral and cellular partners that mediate early host responses to HCMV, the interaction between structural components of virions and cellular receptors, the reactions of innate immune cells, the numerous mechanisms of viral immunoevasion, and the potential exploitation of events that are associated with early phases of virus-host interplay as a therapeutic strategy.

TL;DR: IFI16 is implicate as a novel restriction factor against HCMV replication and new insight is provided into the physiological functions of the IFN-inducible gene IFI16 as a viral restriction factor.

TL;DR: It is demonstrated that the HSV-1 capsid was ubiquitinated in the cytosol and degraded by the proteasome, hence releasing genomic DNA into the cytoplasm for detection by DNA sensors, which is important for induction of IFN-β in human macrophages postinfection with HSv-1 and CMV.

TL;DR: The monoclonal antibody produced by fusing the murine nonsecreting myeloma cell line P3.X63.653 with spleen cells from rats immunized with IFN-gamma-containing supernatants obtained by stimulating a T-cell lymphoma, L12-R4, with phorbol 12-myristate 13-acetate.