K
Kathrine Hansen
Researcher at Aarhus University
Publications - 6
Citations - 816
Kathrine Hansen is an academic researcher from Aarhus University. The author has contributed to research in topics: Innate immune system & IFI16. The author has an hindex of 5, co-authored 6 publications receiving 684 citations.
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Journal ArticleDOI
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
Martin R. Jakobsen,Rasmus O. Bak,Annika Andersen,Randi K. Berg,Randi K. Berg,Søren B. Jensen,Tengchuan Jin,Anders Laustsen,Kathrine Hansen,Lars Østergaard,Katherine A. Fitzgerald,T. Sam Xiao,Jacob Giehm Mikkelsen,Trine H. Mogensen,Søren R. Paludan +14 more
TL;DR: IFI16 is a sensor for DNA forms produced during the lentiviral replication cycle and regulates HIV-1 replication in macrophages, which contribute to early control of the virus.
Journal ArticleDOI
Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway
Kathrine Hansen,Thaneas Prabakaran,Anders Laustsen,Sofie E. Jørgensen,Stine H Rahbæk,Søren B. Jensen,Rikke Nielsen,Jess H. Leber,Thomas Decker,Kristy A. Horan,Martin R. Jakobsen,Søren R. Paludan +11 more
TL;DR: In human macrophages, Listeria DNA rather than cyclic‐di‐AMP is stimulating the IFN response via a pathway dependent on the DNA sensors IFI16 and cGAS as well as the signalling adaptor molecule STING.
Journal ArticleDOI
Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors
Kristy A. Horan,Kathrine Hansen,Martin R. Jakobsen,Christian K. Holm,Stine Søby,Leonie Unterholzner,Mikayla R. Thompson,John A. West,Marie B. Iversen,Simon B. Rasmussen,Svend Ellermann-Eriksen,Evelyn A. Kurt-Jones,Santo Landolfo,Blossom Damania,Jesper Melchjorsen,Andrew G. Bowie,Katherine A. Fitzgerald,Søren R. Paludan +17 more
TL;DR: It is demonstrated that the HSV-1 capsid was ubiquitinated in the cytosol and degraded by the proteasome, hence releasing genomic DNA into the cytoplasm for detection by DNA sensors, which is important for induction of IFN-β in human macrophages postinfection with HSv-1 and CMV.
Journal ArticleDOI
Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection
Chenglong Sun,Stefan A. Schattgen,Prapaporn Pisitkun,Prapaporn Pisitkun,Joan P. Jorgensen,Adam T. Hilterbrand,Lucas Wang,John A. West,Kathrine Hansen,Kristy A. Horan,Martin R. Jakobsen,Peter O'Hare,Heiko Adler,Ren Sun,Hidde L. Ploegh,Blossom Damania,Jason W. Upton,Katherine A. Fitzgerald,S�ren R. Paludan +18 more
TL;DR: In this paper, the deubiquitinase (DUB) activity was found to play only a minor role in the control of MHV68 infections in vivo, which was associated with impaired delivery of viral DNA to the nucleus, instead localized to the cytoplasm.
Journal ArticleDOI
Peer influence on adolescent snacking
TL;DR: In this paper, the authors explore peer influence and the social and symbolic meaning that adolescents attach to snacks; investigate the relative influence of peer influence compared to personal factors in explaining perceived importance of snack attributes; and investigate age and gender differences in the peer influence process.