S
Sarah E. Church
Researcher at Paris Descartes University
Publications - 21
Citations - 2914
Sarah E. Church is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 9, co-authored 9 publications receiving 2050 citations. Previous affiliations of Sarah E. Church include French Institute of Health and Medical Research & University of Paris.
Papers
More filters
Journal ArticleDOI
Complement System Part I - Molecular Mechanisms of Activation and Regulation
Nicolas S. Merle,Nicolas S. Merle,Nicolas S. Merle,Sarah E. Church,Sarah E. Church,Sarah E. Church,Véronique Frémeaux-Bacchi,Lubka T. Roumenina,Lubka T. Roumenina,Lubka T. Roumenina +9 more
TL;DR: This article will review the mechanisms of activation of alternative, classical, and lectin pathways, the formation of C3 and C5 convertases, the action of anaphylatoxins, and the membrane-attack-complex, and discuss the importance of structure–function relationships.
Journal ArticleDOI
Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability
Bernhard Mlecnik,Bernhard Mlecnik,Bernhard Mlecnik,Gabriela Bindea,Gabriela Bindea,Gabriela Bindea,Helen K. Angell,Pauline Maby,Mihaela Angelova,David Tougeron,Sarah E. Church,Sarah E. Church,Sarah E. Church,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Maria Fischer,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Maristella Sasso,Maristella Sasso,Maristella Sasso,Amélie M. Bilocq,Amélie M. Bilocq,Amélie M. Bilocq,Amos Kirilovsky,Amos Kirilovsky,Amos Kirilovsky,Anna C. Obenauf,Mohamad Hamieh,Anne Berger,Patrick Bruneval,Jean-Jacques Tuech,Jean-Christophe Sabourin,Florence Le Pessot,Jacques Mauillon,Arash Rafii,Pierre Laurent-Puig,Pierre Laurent-Puig,Michael R. Speicher,Zlatko Trajanoski,Pierre Michel,Richard Sesboüé,Thierry Frebourg,Thierry Frebourg,Franck Pagès,Viia Valge-Archer,Viia Valge-Archer,Jean-Baptiste Latouche,Jérôme Galon,Jérôme Galon,Jérôme Galon +52 more
TL;DR: Assessment of the immune status via Immunoscore provides a potent indicator of tumor recurrence beyond microsatellite-instability staging that could be an important guide for immunotherapy strategies.
Journal ArticleDOI
The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis
Bernhard Mlecnik,Bernhard Mlecnik,Bernhard Mlecnik,Gabriela Bindea,Gabriela Bindea,Gabriela Bindea,Amos Kirilovsky,Amos Kirilovsky,Amos Kirilovsky,Helen K. Angell,Anna C. Obenauf,Marie Tosolini,Marie Tosolini,Marie Tosolini,Sarah E. Church,Sarah E. Church,Sarah E. Church,Pauline Maby,Pauline Maby,Pauline Maby,Angela Vasaturo,Angela Vasaturo,Angela Vasaturo,Mihaela Angelova,Mihaela Angelova,Mihaela Angelova,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Stéphanie Mauger,Stéphanie Mauger,Stéphanie Mauger,Maximilian J. Waldner,Anne Berger,Michael R. Speicher,Franck Pagès,Viia Valge-Archer,Jérôme Galon,Jérôme Galon,Jérôme Galon +39 more
TL;DR: The data demonstrate the protective impact of the Immunoscore, a cytotoxic immune signature, and increased marginal lymphatic vessels, against the generation of distant metastases, regardless of genomic instability.
Journal ArticleDOI
Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival.
Bernhard Mlecnik,Marc Van den Eynde,Gabriela Bindea,Gabriela Bindea,Gabriela Bindea,Sarah E. Church,Sarah E. Church,Sarah E. Church,Angela Vasaturo,Angela Vasaturo,Angela Vasaturo,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Nacilla Haicheur,Florence Marliot,Daphné Debetancourt,Géraldine Pairet,Anne Jouret-Mourin,Jean-François Gigot,Catherine Hubert,Etienne Danse,Cristina Dragean,Javier Carrasco,Yves Humblet,Viia Valge-Archer,Anne Berger,Franck Pagès,Jean-Pascal Machiels,Jérôme Galon,Jérôme Galon,Jérôme Galon +34 more
TL;DR: Responses to treatment and prolonged survival of metastatic CRC patients were statistically significantly associated with high-immune densities quantified into the least immune-infiltrated metastases, which remained the only statistically significant prognostic factor associated with DFS and OS in multivariable analysis.
Journal ArticleDOI
The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients.
Marc Van den Eynde,Bernhard Mlecnik,Gabriela Bindea,Tessa Fredriksen,Sarah E. Church,Lucie Lafontaine,Nacilla Haicheur,Florence Marliot,Mihaela Angelova,Angela Vasaturo,Daniela Bruni,Anne Jouret-Mourin,Pamela Baldin,Nicolas Huyghe,Karin Haustermans,Annelies Debucquoy,Eric Van Cutsem,Jean-François Gigot,Catherine Hubert,Alex Kartheuser,Christophe Remue,Daniel Léonard,Viia Valge-Archer,Franck Pagès,Jean-Pascal Machiels,Jérôme Galon +25 more
TL;DR: The immune phenotype of the least-infiltrated metastasis had a stronger association with patient outcome than other metastases and the predictive accuracy of the Immunoscore from a single biopsy was superior to the one of programmed cell death ligand 1 (PD-L1).