T
Takuya Uehata
Researcher at Kyoto University
Publications - 14
Citations - 642
Takuya Uehata is an academic researcher from Kyoto University. The author has contributed to research in topics: Immune system & RNA. The author has an hindex of 9, co-authored 14 publications receiving 431 citations. Previous affiliations of Takuya Uehata include Prevention Institute & Japan Agency for Medical Research and Development.
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Journal ArticleDOI
Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms
Takashi Mino,Yasuhiro Murakawa,Akira Fukao,Alexis Vandenbon,Hans-Hermann Wessels,Daisuke Ori,Takuya Uehata,Sarang Tartey,Shizuo Akira,Yutaka Suzuki,Carola G. Vinuesa,Uwe Ohler,Daron M. Standley,Markus Landthaler,Toshinobu Fujiwara,Osamu Takeuchi +15 more
TL;DR: It is shown that, although Regnase-1 and Roquin regulate an overlapping set of mRNAs via a common stem-loop structure, they function in distinct subcellular locations: ribosome/endoplasmic reticulum and processing-body/stress granules, respectively.
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NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements
Shigeki Hirabayashi,Shruti Bhagat,Yu Matsuki,Yujiro Takegami,Takuya Uehata,Takuya Uehata,Ai Kanemaru,Masayoshi Itoh,Kotaro Shirakawa,Akifumi Takaori-Kondo,Osamu Takeuchi,Osamu Takeuchi,Piero Carninci,Shintaro Katayama,Yoshihide Hayashizaki,Juha Kere,Hideya Kawaji,Yasuhiro Murakawa +17 more
TL;DR: A simple and robust method, native elongating transcript–cap analysis of gene expression (NET-CAGE), to sensitively detect 5′ ends of nascent RNAs in diverse cells and tissues, including unstable transcripts such as enhancer-derived RNAs, and shows that enhancer–promoter pairs are generally activated simultaneously.
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Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs
Masanori Yoshinaga,Yoshinari Nakatsuka,Yoshinari Nakatsuka,Alexis Vandenbon,Daisuke Ori,Takuya Uehata,Takuya Uehata,Tohru Tsujimura,Yutaka Suzuki,Takashi Mino,Takashi Mino,Osamu Takeuchi,Osamu Takeuchi +12 more
TL;DR: It is demonstrated that Regnase-1-mediated regulation of iron-related transcripts is essential for the maintenance of iron homeostasis.
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N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation
Daichi Yamasoba,Kei Sato,Takuya Ichinose,Takuya Ichinose,Tomoko Imamura,Lennart Koepke,Simone Joas,Elisabeth Reith,Dominik Hotter,Naoko Misawa,Kotaro Akaki,Kotaro Akaki,Takuya Uehata,Takuya Uehata,Takashi Mino,Takashi Mino,Sho Miyamoto,Takeshi Noda,Akio Yamashita,Daron M. Standley,Frank Kirchhoff,Daniel Sauter,Yoshio Koyanagi,Osamu Takeuchi,Osamu Takeuchi +24 more
TL;DR: It is demonstrated that the RNase N4BP1 is an efficient restriction factor of HIV-1 and suggested that inactivation of N4 BP1 by induction of MALT1 activation might facilitate elimination of latent HIV- 1 reservoirs.
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The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells
Kazuko Miyazaki,Hitomi Watanabe,Genki Yoshikawa,Kenian Chen,Reiko Hidaka,Yuki Aitani,Kai Osawa,Rie Takeda,Yotaro Ochi,Shizue Tani-ichi,Takuya Uehata,Osamu Takeuchi,Koichi Ikuta,Seishi Ogawa,Seishi Ogawa,Gen Kondoh,Yin C. Lin,Hiroyuki Ogata,Masaki Miyazaki +18 more
TL;DR: Three key enhancer elements are identified that recruit the transcription factor E2A to promote the expression of Rag1 and Rag2 genes during lymphocyte development and are identified as cis-regulatory elements and two B cell–specific elements.