S
Sawako Itagaki
Researcher at Osaka University
Publications - 25
Citations - 1308
Sawako Itagaki is an academic researcher from Osaka University. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 13, co-authored 24 publications receiving 1192 citations. Previous affiliations of Sawako Itagaki include University of Kinshasa.
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Journal ArticleDOI
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
Cevayir Coban,Ken Ishii,Taro Kawai,Hiroaki Hemmi,Shintaro Sato,Satoshi Uematsu,Masahiro Yamamoto,Osamu Takeuchi,Sawako Itagaki,Nirbhay Kumar,Toshihiro Horii,Shizuo Akira +11 more
TL;DR: This work demonstrates that HZ purified from Plasmodium falciparum is a novel non-DNA ligand for Toll-like receptor (TLR)9, and activation by HZ activated innate immune responses in vivo and in vitro, resulting in the production of cytokines, chemokines, and up-regulation of costimulatory molecules.
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Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors
Fumiji Saito,Kouyuki Hirayasu,Takeshi Satoh,Christian W. Wang,Christian W. Wang,John Lusingu,Takao Arimori,Kyoko Shida,Nirianne Marie Q. Palacpac,Sawako Itagaki,Shiroh Iwanaga,Shiroh Iwanaga,Eizo Takashima,Takafumi Tsuboi,Masako Kohyama,Tadahiro Suenaga,Marco Colonna,Junichi Takagi,Thomas Lavstsen,Thomas Lavstsen,Toshihiro Horii,Hisashi Arase +21 more
TL;DR: It is shown that P. falciparum uses immune inhibitory receptors to achieve immune evasion, and has acquired multiple RIFINs to evade the host immune system by targeting immune inhibitsory receptors.
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Serine Repeat Antigen (SERA5) Is Predominantly Expressed among the SERA Multigene Family of Plasmodium falciparum, and the Acquired Antibody Titers Correlate with Serum Inhibition of the Parasite Growth
Sayaka Aoki,Jie Li,Sawako Itagaki,Brenda Okech,Thomas G. Egwang,Hiroyuki Matsuoka,Nirianne Marie Q. Palacpac,Toshihide Mitamura,Toshihiro Horii +8 more
TL;DR: Northern blotting and real time quantitative reverse transcription-PCR with five independent parasite strains have shown that all of the SERA homologues are transcribed most actively at trophozoite and schizont stages and that SERA5 (SERA/SERP) is transcribed predominantly among the family.
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Phase 1b Randomized Trial and Follow-Up Study in Uganda of the Blood-Stage Malaria Vaccine Candidate BK-SE36
Nirianne Marie Q. Palacpac,Edward H. Ntege,Adoke Yeka,Betty Balikagala,Nahoko Suzuki,Hiroki Shirai,Masanori Yagi,Kazuya Ito,Wakaba Fukushima,Yoshio Hirota,Christopher Nsereko,Takuya Okada,Bernard N. Kanoi,Kohhei Tetsutani,Nobuko Arisue,Sawako Itagaki,Takahiro Tougan,Ken Ishii,Shigeharu Ueda,Thomas G. Egwang,Toshihiro Horii +20 more
TL;DR: The promising potential of BK-SE36, observed in the follow-up study, warrants a double-blind phase 1/2b trial in children under 5 years.
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New readily accessible peroxides with High Anti-malarial Potency
TL;DR: 6-carbomethoxymethyl-3-methoxy- 3-pentyl-1,2-dioxane, which has been readily synthesized from 6-keto-alpha,beta-unsaturated ester, was found to exhibit potent anti-malarial activity with high selective toxicity.