S
Scott J Robbie
Researcher at UCL Institute of Ophthalmology
Publications - 37
Citations - 3460
Scott J Robbie is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Macular degeneration & Choroidal neovascularization. The author has an hindex of 16, co-authored 35 publications receiving 3146 citations. Previous affiliations of Scott J Robbie include University of Murcia & University College London.
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Journal ArticleDOI
Effect of gene therapy on visual function in Leber's congenital amaurosis.
James W B Bainbridge,Alexander J. Smith,Susie S Barker,Scott J Robbie,Robert H. Henderson,Kamaljit S. Balaggan,Ananth C. Viswanathan,Graham E. Holder,Andrew Stockman,Nick Tyler,Simon M. Petersen-Jones,Shomi S. Bhattacharya,Adrian J. Thrasher,Fred W. Fitzke,Barrie J Carter,Gary S. Rubin,Anthony T. Moore,Robin R. Ali +17 more
TL;DR: Three young adult patients with early-onset, severe retinal dystrophy were administered subretinal injections of recombinant adeno-associated virus vector 2/2 expressing RPE65 complementary DNA (cDNA) under the control of a human R PE65 promoter.
Journal ArticleDOI
Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis
James W B Bainbridge,James W B Bainbridge,Manjit S Mehat,Venki Sundaram,Scott J Robbie,S. E. Barker,Caterina Ripamonti,Anastasios Georgiadis,Anastasios Georgiadis,Freya M. Mowat,Freya M. Mowat,Stuart G Beattie,Peter Gardner,Kecia L. Feathers,Vy Luong,Suzanne Yzer,Kamaljit S. Balaggan,Kamaljit S. Balaggan,Ananth C. Viswanathan,Thomy de Ravel,Ingele Casteels,Graham E. Holder,Nick Tyler,Fred W. Fitzke,Richard G. Weleber,Marko Nardini,Marko Nardini,Anthony T. Moore,Anthony T. Moore,Debra A. Thompson,Simon M. Petersen-Jones,Michel Michaelides,Michel Michaelides,L. Ingeborgh van den Born,Andrew Stockman,Alexander J. Smith,Gary S. Rubin,Robin R. Ali,Robin R. Ali +38 more
TL;DR: In dogs, RPE65 gene therapy with the same vector at lower doses improved vision-guided behavior, but only higher doses resulted in improvements in retinal function that were detectable with the use of ERG, and comparison with the results obtained in the dog model indicates that there is a species difference in the amount of R PE65 required to drive the visual cycle.
Journal ArticleDOI
The Drusenlike Phenotype in Aging Ccl2-Knockout Mice Is Caused by an Accelerated Accumulation of Swollen Autofluorescent Subretinal Macrophages
Ulrich F O Luhmann,Scott J Robbie,Peter M. G. Munro,S. E. Barker,Yanai Duran,Vy Luong,Fred W. Fitzke,James W B Bainbridge,Robin R. Ali,Robert E MacLaren +9 more
TL;DR: The findings suggest that the lack of Ccl2 leads to a monocyte/macrophage-trafficking defect during aging and to an impaired recruitment of these cells to sites of laser injury.
Journal ArticleDOI
Long-term preservation of cones and improvement in visual function following gene therapy in a mouse model of leber congenital amaurosis caused by guanylate cyclase-1 deficiency.
Marija Mihelec,Rachael A. Pearson,Scott J Robbie,Prateek K. Buch,Selina A. Azam,James W B Bainbridge,Alexander J. Smith,Robin R. Ali +7 more
TL;DR: This is the most effective rescue of the Gucy2e(-/-) mouse model of LCA and it is proposed that a vector, similar to the one used in this study, could be suitable for use in a clinical trial of gene therapy for LCA1.
Journal ArticleDOI
Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65
Anastasios Georgiadis,Yanai Duran,Joana Ribeiro,Laura Abelleira-Hervas,Scott J Robbie,B Sünkel-Laing,S Fourali,Anai Gonzalez-Cordero,Enrico Cristante,Michel Michaelides,Michel Michaelides,James W B Bainbridge,James W B Bainbridge,Alexander J. Smith,Robin R. Ali,Robin R. Ali +15 more
TL;DR: It is concluded that the demand for RPE65 in humans is not fully met by current vectors, and it is predicted that a more powerful vector will provide more durable benefit.