Sean M. Riordan

TL;DR: The results reveal novel information on dynamic BACE1 transport in neurons, and demonstrate that Rab11-GTPase function is critical for axonal sorting of Bace1.

TL;DR: Both intraneuronal Aβ accumulation and extracellular A β deposition was demonstrated in 5xFAD mice and 3xTg mice with MOAB-2, an antibody that will help differentiate intracellular Aβ from APP, however, further investigation is required to determine whether a molecular mechanism links the presence of intraneuonal A β with neurotoxicity.

TL;DR: The results imply the possibility that axon mis-targeting may occur in adult neurogenic and/or regenerating neurons as a result of chronic Bace1 inhibition and add a note of caution to BACE1 inhibitor development.

TL;DR: Adopting a systematic nomenclature for the spectrum of clinical consequences of hyperbilirubinemia will help unify the field and promote more effective research in both prevention and treatment of KSDs.

TL;DR: Examination of synaptic transmission during long sustained trains of activity suggested that the readily releasable pool of vesicles is reduced in Epac2−/− mice, and data suggest that cAMP elevation uses an Epac 2-dependent pathway to promote transmitter release, and thatEpac2 is required to maintain the readily RELEASable pool at MF synapses in the hippocampus.