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Sean O. Hynes
Researcher at National University of Ireland, Galway
Publications - 72
Citations - 2201
Sean O. Hynes is an academic researcher from National University of Ireland, Galway. The author has contributed to research in topics: Helicobacter pylori & Medicine. The author has an hindex of 25, co-authored 64 publications receiving 1975 citations. Previous affiliations of Sean O. Hynes include University College Hospital & Lund University.
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Journal ArticleDOI
Mersacidin eradicates methicillin-resistant Staphylococcus aureus (MRSA) in a mouse rhinitis model
TL;DR: In the mouse rhinitis model, mers acidin was able to eradicate MRSA colonization and the site of action (epithelium versus blood) of mersacidin needs to be further explored.
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Simultaneous expression of type 1 and type 2 Lewis blood group antigens by Helicobacter pylori lipopolysaccharides. Molecular mimicry between h. pylori lipopolysaccharides and human gastric epithelial cell surface glycoforms.
Mario A. Monteiro,Kenneth Chan,David A. Rasko,Diane E. Taylor,P.Y. Zheng,Ben J. Appelmelk,Hans-Peter Wirth,Manqiao Yang,Martin J. Blaser,Sean O. Hynes,Anthony P. Moran,Malcolm B. Perry +11 more
TL;DR: That monoclonal antibodies putatively specific for the Leb determinant can detect glycan substructures (Le disaccharide, Lec, and Led) of Leb indicates their nonspecificity.
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Superparamagnetic Iron Oxide Nanoparticle Targeting of MSCs in Vascular Injury
Johannes Riegler,Aaron Liew,Sean O. Hynes,Daniel Ortega,Timothy O'Brien,Richard M. Day,Toby Richards,Faisal Sharif,Quentin A. Pankhurst,Quentin A. Pankhurst,Mark F. Lythgoe +10 more
TL;DR: It is shown that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent magnet.
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Lipopolysaccharide structures of Helicobacter pylori genomic strains 26695 and J99, mouse model H. pylori Sydney strain, H. pylori P466 carrying sialyl Lewis X, and H. pylori UA915 expressing Lewis B
Mario A. Monteiro,Ben J. Appelmelk,David A. Rasko,Anthony P. Moran,Sean O. Hynes,Leann L. MacLean,Ken H. Chan,Frank St. Michael,Susan M. Logan,Jani O'Rourke,Adrian Lee,Diane E. Taylor,Malcolm B. Perry +12 more
TL;DR: The molecular makeup of the cell-wall lipopolysaccharides (LPSs) from five Helicobacter pylori strains should aid investigations that focus on identifying and characterizing genes responsible for LPS biosynthesis in genomic strains 26695 and J99, and in understanding the role of H. pyloro LPS in animal model studies.
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Phenotypic Variation in Molecular Mimicry betweenHelicobacter pylori Lipopolysaccharides and Human Gastric Epithelial Cell Surface Glycoforms ACID-INDUCED PHASE VARIATION IN LEWISXAND LEWISY EXPRESSION BY H. PYLORILIPOPOLYSACCHARIDES
Anthony P. Moran,Yuriy A. Knirel,Sof'ya N. Senchenkova,Göran Widmalm,Sean O. Hynes,Per-Erik Jansson +5 more
TL;DR: This is the first report identifying an environmental trigger inducing phase variation of Le(x) and Le(y) in H. pylori that can aid adaptation of the bacterium to its ecological niche.