S
Sean W. Robinson
Researcher at Schrödinger
Publications - 4
Citations - 60
Sean W. Robinson is an academic researcher from Schrödinger. The author has contributed to research in topics: Cyclin-dependent kinase & GSK-3. The author has an hindex of 2, co-authored 4 publications receiving 28 citations. Previous affiliations of Sean W. Robinson include Rutherford Appleton Laboratory.
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Journal ArticleDOI
Studies on the Inhibition of AmpC and other β-Lactamases by Cyclic Boronates
Samuel T. Cahill,Jonathan M. Tyrrell,Iva Navratilova,Karina Calvopiña,Sean W. Robinson,Christopher T. Lohans,Michael A. McDonough,Ricky Cain,Colin W. G. Fishwick,Matthew B. Avison,Timothy R. Walsh,Christopher J. Schofield,Jürgen Brem +12 more
TL;DR: Biophysical studies support the proposal that bicyclic boronates mimic tetrahedral intermediates common to SBL and MBL catalysis, and further support the promise of such compounds as broad spectrum β-lactamase inhibitors.
Journal ArticleDOI
Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.
M.A. Redhead,C. David Owen,Lennart Brewitz,Amelia H. Collette,Petra Lukacik,Claire Strain-Damerell,Sean W. Robinson,Patrick Collins,Philipp Schäfer,Mark Swindells,Chris J Radoux,Iva Navratilova Hopkins,D. Fearon,Alice Douangamath,Frank von Delft,Tika R. Malla,Laura Vangeel,Thomas Vercruysse,Jan Thibaut,Pieter Leyssen,Tu Trinh Nguyen,Mitchell V. Hull,Anthony Tumber,David J. Hallett,Christopher J. Schofield,David I. Stuart,A.L. Hopkins,Martin A. Walsh +27 more
TL;DR: In this paper, the authors describe the discovery of two non-antiviral therapeutic agents, the caspase-1 inhibitor SDZ 224015 and Tarloxotinib that target Mpro and PLpro, respectively.
Journal ArticleDOI
Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.
Scott H. Henderson,Fiona J. Sorrell,Jim Bennett,Marcus T. Hanley,Sean W. Robinson,Iva Navratilova,Iva Navratilova,Jonathan M. Elkins,Jonathan M. Elkins,Simon E. Ward +9 more
TL;DR: This work presents a pipeline of open-source software that analyzes public domain data to repurpose compounds that have been used in previous kinase inhibitor development projects to deliver 8b, a highly selective DYRK1A inhibitor.
Journal ArticleDOI
Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors
Scott H. Henderson,Fiona J. Sorrell,Jim Bennett,Oleg Fedorov,Marcus T. Hanley,P.H.C. Godoi,Roberta Regina Ruela de Sousa,Sean W. Robinson,Alexander Ashall-Kelly,Iva Navratilova,Iva Navratilova,Daryl S. Walter,Jonathan M. Elkins,Jonathan M. Elkins,Simon E. Ward +14 more
TL;DR: In this paper, a series of pyrazolo[1,5-b]pyridazine inhibitors with excellent ligand efficiencies, good physicochemical properties, and a high degree of selectivity over the kinome are presented.