S
Sebastian Loos
Researcher at University of Hamburg
Publications - 20
Citations - 694
Sebastian Loos is an academic researcher from University of Hamburg. The author has contributed to research in topics: Medicine & Eculizumab. The author has an hindex of 7, co-authored 14 publications receiving 636 citations.
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Journal ArticleDOI
Open-Source Genomic Analysis of Shiga-Toxin–Producing E. coli O104:H4
Holger Rohde,Junjie Qin,Yujun Cui,Dongfang Li,Nicholas J. Loman,Moritz Hentschke,Wentong Chen,Fei Pu,Yangqing Peng,Junhua Li,Feng Xi,Shenghui Li,Yin Li,Zhaoxi Zhang,Xianwei Yang,Meiru Zhao,Peng Wang,Yuanlin Guan,Zhong Cen,Xiangna Zhao,Martin Christner,Robin Kobbe,Sebastian Loos,Jun Oh,Liang Yang,Antoine Danchin,George F. Gao,Yajun Song,Yingrui Li,Huanming Yang,Jian Wang,Jianguo Xu,Mark J. Pallen,Jun Wang,Martin Aepfelbacher,Ruifu Yang +35 more
TL;DR: A cluster of cases associated with a single family is reported and an open-source genomic analysis of an isolate from one member of the family is described, revealing that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance.
Journal ArticleDOI
An Outbreak of Shiga Toxin–Producing Escherichia coli O104:H4 Hemolytic Uremic Syndrome in Germany: Presentation and Short-term Outcome in Children
Sebastian Loos,Thurid Ahlenstiel,Brigitta Kranz,Hagen Staude,Lars Pape,Christoph Härtel,Udo Vester,Laura Buchtala,Kerstin Benz,Bernd Hoppe,Ortraud Beringer,Martin Krause,Dominik N. Müller,Martin Pohl,Johanna Lemke,Georg Hillebrand,Martin Kreuzer,Jens König,Marianne Wigger,Martin Konrad,Dieter Haffner,Jun Oh,Markus J. Kemper +22 more
TL;DR: Initial morbidity, as well as short-term outcome, due to this pathogen, is comparable to previous pediatric series of Shiga toxin-producing E. coli HUS.
Journal ArticleDOI
Intermediate Follow-up of Pediatric Patients With Hemolytic Uremic Syndrome During the 2011 Outbreak Caused by E. coli O104:H4.
Sebastian Loos,Wiebke Aulbert,Bernd Hoppe,Thurid Ahlenstiel-Grunow,Birgitta Kranz,Charlotte Wahl,Hagen Staude,Alexander Humberg,Kerstin Benz,Martin Krause,Martin Pohl,Max C. Liebau,Raphael Schild,Johanna Lemke,Ortraud Beringer,Dominik N. Müller,Christoph Härtel,Marianne Wigger,Udo Vester,Martin Konrad,Dieter Haffner,Lars Pape,Jun Oh,Markus J. Kemper +23 more
TL;DR: The overall outcome of pediatric patients after H US due to E. coli O104:H4 was equivalent to previous reports on HUS due to other types of Shiga toxin-producing E coli (STEC).
Journal ArticleDOI
Neurological involvement in children with E. coli O104:H4-induced hemolytic uremic syndrome
Angela Bauer,Sebastian Loos,Carola Wehrmann,Dirk Horstmann,Frank Donnerstag,Johanna Lemke,Georg Hillebrand,Ulrike Löbel,Lars Pape,Dieter Haffner,Carola Bindt,Thurid Ahlenstiel,Anette Melk,Anja Lehnhardt,Markus J. Kemper,Jun Oh,Hans Hartmann +16 more
TL;DR: The incidence of pathological EEG findings was high, even in patients without clinical signs of neurological involvement, Nevertheless, major neurological sequelae were rare, and neuropsychological outcome was favorable after 6 months.
Journal ArticleDOI
Serum Shiga toxin 2 values in patients during acute phase of diarrhoea-associated haemolytic uraemic syndrome.
Xiaohua He,Beatriz Quiñones,Maroeska te Loo,Sebastian Loos,Gaia Scavia,Maurizio Brigotti,Elena Levtchenko,Leo A. H. Monnens +7 more
TL;DR: The concentration of Shiga toxin 2 (Stx2) in the serum of children affected in by HUS due to Stx2 producing Escherichia coli was measured to show associations with diarrhoea‐associated haemolytic uraemic syndrome.