Meiru Zhao

TL;DR: The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations, and has reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-generation sequencing, deep exome sequencing, and dense microarray genotyping.

TL;DR: The 1000 Genomes Project as mentioned in this paper provided a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations, and reported the completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole genome sequencing, deep exome sequencing and dense microarray genotyping.

TL;DR: A population genomic survey has revealed a functionally important locus in genetic adaptation to high altitude, and the strongest signal of natural selection came from endothelial Per-Arnt-Sim domain protein 1 (EPAS1), a transcription factor involved in response to hypoxia.

TL;DR: A cluster of cases associated with a single family is reported and an open-source genomic analysis of an isolate from one member of the family is described, revealing that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance.

TL;DR: RCHSBT—reliable, cost‐effective and high‐throughput sequence based typing pipeline—which takes short sequence reads as input, but uses a unique variant calling, haploid sequence assembling algorithm, can accurately genotype with greater effective length per amplicon than even Sanger sequencing reads.