S
Sebiha Cevik
Researcher at Abdullah Gül University
Publications - 22
Citations - 4616
Sebiha Cevik is an academic researcher from Abdullah Gül University. The author has contributed to research in topics: Cilium & Intraflagellar transport. The author has an hindex of 9, co-authored 15 publications receiving 4339 citations. Previous affiliations of Sebiha Cevik include University College Dublin & Harvard University.
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Journal ArticleDOI
Towards a proteome-scale map of the human protein–protein interaction network
Jean François Rual,Kavitha Venkatesan,Tong Hao,Tomoko Hirozane-Kishikawa,Amélie Dricot,Ning Li,Gabriel F. Berriz,Francis D. Gibbons,Matija Dreze,Nono Ayivi-Guedehoussou,Niels Klitgord,Christophe Simon,Mike Boxem,Stuart Milstein,Jennifer Rosenberg,Debra S. Goldberg,Lan V. Zhang,Sharyl L. Wong,Giovanni Franklin,Siming Li,Joanna S. Albala,Joanna S. Albala,Janghoo Lim,Carlene Fraughton,Estelle Llamosas,Sebiha Cevik,Camille Bex,Philippe Lamesch,Robert S. Sikorski,Jean Vandenhaute,Huda Y. Zoghbi,Alex Smolyar,Stephanie Bosak,Reynaldo Sequerra,Lynn Doucette-Stamm,Michael E. Cusick,David E. Hill,Frederick P. Roth,Marc Vidal +38 more
TL;DR: An initial version of a proteome-scale map of human binary protein–protein interactions is described, which increases by ∼70% the set of available binary interactions within the tested space and reveals more than 300 new connections to over 100 disease-associated proteins.
Journal ArticleDOI
An empirical framework for binary interactome mapping
Kavitha Venkatesan,Kavitha Venkatesan,Jean François Rual,Alexei Vazquez,Alexei Vazquez,Ulrich Stelzl,Irma Lemmens,Tomoko Hirozane-Kishikawa,Tong Hao,Martina Zenkner,Xiaofeng Xin,Kwang-Il Goh,Kwang-Il Goh,Kwang-Il Goh,Muhammed A. Yildirim,Nicolas Simonis,Kathrin Heinzmann,Fana Gebreab,Julie M. Sahalie,Sebiha Cevik,Sebiha Cevik,Christophe Simon,Anne Sophie de Smet,Elizabeth Dann,Alex Smolyar,Arunachalam Vinayagam,Haiyuan Yu,David Szeto,Heather Borick,Heather Borick,Amélie Dricot,Niels Klitgord,Niels Klitgord,Ryan R. Murray,Chenwei Lin,Maciej Lalowski,Jan Timm,Kirstin Rau,Charles Boone,Pascal Braun,Michael E. Cusick,Frederick P. Roth,David E. Hill,Jan Tavernier,Erich E. Wanker,Albert-László Barabási,Albert-László Barabási,Marc Vidal +47 more
TL;DR: The results indicate that high-throughput yeast two-hybrid interactions for human proteins are more precise than literature-curated interactions supported by a single publication, suggesting that HT-Y2H is suitable to map a significant portion of the human interactome.
Journal ArticleDOI
Empirically-controlled mapping of the Caenorhabditis elegans protein-protein interactome network
Nicolas Simonis,Jean François Rual,Anne-Ruxandra Carvunis,Murat Tasan,Irma Lemmens,Tomoko Hirozane-Kishikawa,Tong Hao,Julie M. Sahalie,Kavitha Venkatesan,Fana Gebreab,Sebiha Cevik,Niels Klitgord,Changyu Fan,Pascal Braun,Ning Li,Nono Ayivi-Guedehoussou,Elizabeth Dann,Nicolas Bertin,David Szeto,Amélie Dricot,Muhammed A. Yildirim,Chenwei Lin,Anne Sophie de Smet,Huey Ling Kao,Christophe Simon,Alex Smolyar,Jin Sook Ahn,Muneesh Tewari,Mike Boxem,Stuart Milstein,Haiyuan Yu,Matija Dreze,Jean Vandenhaute,Kristin C. Gunsalus,Michael E. Cusick,David E. Hill,Jan Tavernier,Frederick P. Roth,Marc Vidal +38 more
TL;DR: This work filtered previous interaction data sets and integrated them with WI-2007 to generate a high-confidence consolidated map, which allowed us to estimate the size of the worm interactome at ∼116,000 interactions, and shows the complementarity of distinct experimental approaches in predicting different functional relationships between genes or proteins.
Journal ArticleDOI
Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans
Sebiha Cevik,Yuji Hori,Oktay I. Kaplan,Katarzyna Kida,Tiina Toivenon,Christian Foley-Fisher,David C. Cottell,Toshiaki Katada,Kenji Kontani,Oliver E. Blacque +9 more
TL;DR: The small GTPase Arl13b regulates ciliary transmembrane protein localizations and anterograde IFT assembly stability.
Journal ArticleDOI
Intraflagellar transport: from molecular characterisation to mechanism.
TL;DR: A comprehensive review of intraflagellar transport is presented, with particular emphasis on its molecular composition and mechanism of action.