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Serge Muyldermans

Researcher at Vrije Universiteit Brussel

Publications -  323
Citations -  30516

Serge Muyldermans is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Single-domain antibody & Antibody. The author has an hindex of 80, co-authored 305 publications receiving 26561 citations. Previous affiliations of Serge Muyldermans include Dalian University of Technology & Université libre de Bruxelles.

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Journal ArticleDOI

Nanobodies as Tools for In Vivo Imaging of Specific Immune Cell Types

Kurt De Groeve, +8 more
- 01 May 2010 - 
TL;DR: Nanobodies represent elegant targeting probes for imaging the in vivo biodistribution of specific immune cell types and reflects the main in vivo locations of the cells recognized by the Nanobodies and is determined by the antigen-binding loops of the nanobodies.
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Camelid single-domain antibody-fragment engineering for (pre)clinical in vivo molecular imaging applications: adjusting the bullet to its target

Jens De Vos, +3 more
- 09 Jul 2013 - 
TL;DR: This work reviews the importance of molecular imaging in the clinic and the use of camelid single-domain antibody-fragments (sdAbs) as in vivo molecular imaging tracers and expects that the development and use of sdAbs as tracers for both preclinical and clinical molecular imaging applications will become widespread.
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An S-layer heavy chain camel antibody fusion protein for generation of a nanopatterned sensing layer to detect the prostate-specific antigen by surface plasmon resonance technology.

Magdalena Pleschberger, +6 more
- 20 Apr 2004 - 
TL;DR: The bacterial cell surface layer (S-layer) protein of Bacillus sphaericus CCM 2177 assembles into a square lattice structure and recognizes a distinct type of secondary cell wall polymer (SCWP) as the proper anchoring structure in the rigid cell wall layer.
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Homo- and Heteronuclear Two-Dimensional NMR Studies of the Globular Domain of Histone H1: Full Assignment, Tertiary Structure, and Comparison with the Globular Domain of Histone H5

Corinne Cerf, +7 more
- 20 Sep 1994 - 
TL;DR: The globular domain of chicken histone H1 (GH1) has been studied by 1H homonuclear and 1H-15N heteronuclear 2D NMR spectroscopy and the location of the most positively charged regions seems to agree with the model where nucleosome binding takes place through contact points located at one DNA terminus and close to the dyad axis of the nucleosomes.
Journal ArticleDOI

Applications of Nanobodies

Serge Muyldermans
- 16 Feb 2021 - 
TL;DR: Unique, functional, homodimeric heavy chain-only antibodies, devoid of light chains, are circulating in the blood of Camelidae, and several Nanobody-based constructs have been designed to develop new therapeutic products.