S
Serge Muyldermans
Researcher at Vrije Universiteit Brussel
Publications - 323
Citations - 30516
Serge Muyldermans is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Single-domain antibody & Antibody. The author has an hindex of 80, co-authored 305 publications receiving 26561 citations. Previous affiliations of Serge Muyldermans include Dalian University of Technology & Université libre de Bruxelles.
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Journal ArticleDOI
Development of 177Lu-nanobodies for radioimmunotherapy of HER2-positive breast cancer: evaluation of different bifunctional chelators.
Matthias D'Huyvetter,An Aerts,Catarina Xavier,Ilse Vaneycken,Nick Devoogdt,Marlies Gijs,Nathalie Impens,Sarah Baatout,Bernard Ponsard,Serge Muyldermans,Serge Muyldermans,Vicky Caveliers,Tony Lahoutte +12 more
TL;DR: The in-house developed anti-HER2 nanobody 2Rs15dHIS can be successfully labeled with (177) Lu using different bifunctional chelators, and both macrocyclic and acyclic chelator show high stability in time.
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Development of vegfr2-specific nanobody pseudomonas exotoxin a conjugated to provide efficient inhibition of tumor cell growth
Mahdi Behdani,Sirous Zeinali,Morteza Karimipour,Hossein Khanahmad,Steve Schoonooghe,Azam Aslemarz,Negar Seyed,Reza Moazami-Godarzi,Farzad Baniahmad,Mahdi Habibi-Anbouhi,Gholamreza Hassanzadeh-Ghassabeh,Serge Muyldermans +11 more
TL;DR: It is demonstrated that this immunotoxin inhibits the proliferation of VEGFR2-expressing cells in vitro and is considered to be a significant achievement in tumor therapy and it forms a basis for further studies in animal models.
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Generation of a functional monomolecular protein lattice consisting of an s-layer fusion protein comprising the variable domain of a camel heavy chain antibody.
Magdalena Pleschberger,Angela Neubauer,Eva M. Egelseer,Stefan Weigert,Brigitte Lindner,Uwe B. Sleytr,Serge Muyldermans,Margit Sára +7 more
TL;DR: The functionality of the fused cAb-Lys3 in the S-layer fusion protein was proved by surface plasmon resonance measurements and Dot blot assays revealed that the accessibility of the fusion functional sequence for the antigen was indepe...
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Parallel selection of multiple anti-infectome Nanobodies without access to purified antigens.
Dirk Saerens,Benoit Stijlemans,Toya Nath Baral,Giang Thanh Nguyen Thi,Ulrich Wernery,Stefan Magez,Patrick De Baetselier,Serge Muyldermans,Katja Conrath +8 more
TL;DR: Nanobodies, camelid-derived single-domain antibody fragments, are a valuable source for validation of novel, not yet identified targets to design new diagnostics and therapeutics.
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Nanoimmunoassay onto a screen printed electrode for HER2 breast cancer biomarker determination
Stéphanie Patris,Pieter De Pauw,Marie Vandeput,Joëlle Huet,Pierre Van Antwerpen,Serge Muyldermans,Jean-Michel Kauffmann +6 more
TL;DR: Determination of HER2 in human cells has been realized and the amperometric signal obtained was proportional to the logarithm of Her2 concentration between 1 and 200 µg/mL and the modified SPE storage stability lasted for at least three weeks.