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Serge Muyldermans
Researcher at Vrije Universiteit Brussel
Publications - 323
Citations - 30516
Serge Muyldermans is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Single-domain antibody & Antibody. The author has an hindex of 80, co-authored 305 publications receiving 26561 citations. Previous affiliations of Serge Muyldermans include Dalian University of Technology & Université libre de Bruxelles.
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Journal ArticleDOI
Efficient Cancer Therapy with a Nanobody-Based Conjugate
Virna Cortez-Retamozo,Natalija Backmann,Peter D. Senter,Ullrich Wernery,Patrick De Baetselier,Serge Muyldermans,Hilde Revets +6 more
TL;DR: In vivo studies demonstrated that the nanobody-enzyme conjugate had an excellent biodistribution profile and induced regressions and cures of established tumor xenografts, making nanobodies promising vehicles for new generation cancer therapeutics.
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Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs.
TL;DR: The easy generation steps and the biophysical properties of these bispecific and bivalent constructs based on camel single-domain antibody fragments makes them particularly attractive for use in therapeutic or diagnostic programs.
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Recognition of antigens by single-domain antibody fragments: the superfluous luxury of paired domains
TL;DR: The mutations and structural adaptations that have taken place to reshape a VH of a Vh-VL pair into a single-domain VHH with retention of a sufficient variability are reviewed.
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The Therapeutic Potential of Nanobodies
TL;DR: Today, bio-medical efforts are entering the subcellular level, which is witnessed with the fast-developing fields of nanomedicine, nanodiagnostics and nanotherapy in conjunction with the implementation of nanoparticles for disease prevention, diagnosis, therapy and follow-up.
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Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae.
Katja Conrath,Marc Lauwereys,Moreno Galleni,André Matagne,Jean-Marie Frère,Jörg Kinne,Lode Wyns,Serge Muyldermans +7 more
TL;DR: Addition of the VHHs to the TEM-1 β-lactamase, expressed on the surface of bacteria, leads to a higher ampicillin sensitivity of the bacteria, which could generate multiple potent inhibitors for all types of β- lactamases.