S
Serge Muyldermans
Researcher at Vrije Universiteit Brussel
Publications - 323
Citations - 30516
Serge Muyldermans is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Single-domain antibody & Antibody. The author has an hindex of 80, co-authored 305 publications receiving 26561 citations. Previous affiliations of Serge Muyldermans include Dalian University of Technology & Université libre de Bruxelles.
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Journal ArticleDOI
A nanobody-based electrochemiluminescent immunosensor for sensitive detection of human procalcitonin
TL;DR: The development of a nanobody-based electrochemiluminescent immunosensor for procalcitonin quantification with highly specific and enhanced sensitivity was achieved by CdTe quantum dot encapsulated silica nanoparticle-assisted signal amplification.
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Single domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge
Francisco Miguel Lopez Cardoso,Lorena Itatí Ibañez,Silvie Van den Hoecke,Sarah De Baets,Anouk Smet,Kenny Roose,Bert Schepens,Francis J. Descamps,Walter Fiers,Serge Muyldermans,Ann Depicker,Xavier Saelens +11 more
TL;DR: It is shown that single-domain antibodies directed against influenza virus NA protect against H5N1 virus infection, and when engineered with a conventional Fc domain, they can do so in the absence of detectable NA-inhibitory activity.
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Generation and characterization of nanobodies targeting PSMA for molecular imaging of prostate cancer
Mehdi Evazalipour,Mehdi Evazalipour,Matthias D'Huyvetter,Bahram Soltani Tehrani,Mohsen Abolhassani,Kobra Omidfar,Shahriyar Abdoli,Roghaye Arezumand,Hamid Morovvati,Tony Lahoutte,Serge Muyldermans,Nick Devoogdt +11 more
TL;DR: PSMA30 nanobodies has improved targeting characteristics both in vitro as well as in vivo compared with PSMA6 and the control nanobody, and was therefore selected as the in-house-developed lead compound for PSMA targeting.
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Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies
Miguel Lemaire,Matthias D'Huyvetter,Tony Lahoutte,E Van Valckenborgh,Eline Menu,E. De Bruyne,P Kronenberger,Ulrich Wernery,Serge Muyldermans,Nick Devoogdt,Karin Vanderkerken +10 more
TL;DR: The M-protein present in the murine 5T2MM model is taken advantage of to prove the potential use of Nanobodies in MM and select, produce and purify a panel of very specific anti-5T2 MM-idiotype Nanobodied that recognize nearby epitopes on the idiotype.
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Degenerate interfaces in antigen-antibody complexes.
Klaas Decanniere,Thomas R. Transue,Aline Desmyter,Dominique Maes,Serge Muyldermans,Lode Wyns +5 more
TL;DR: The results show that protein-protein interface characteristics can vary significantly between different specimens of the same high-affinity antibody-protein antigen complex, and consideration should be given to this type of observation when trying to establish general protein- protein interface characteristics.