Serge Muyldermans

TL;DR: In this paper, the authors focus on methodologies to generate cell plasma membrane transport protein-targeting nanobodies, and the advantages and pitfalls while generating these small antibody-derivatives, and discuss several therapeutic nanobody directed towards transmembrane proteins, including channels and pores, adenosine triphosphate-powered pumps and porters.

TL;DR: The state-of-the-art targeting of VEGF/VEGFR and delivery of its inhibitors with liposomal nanocarriers is described and should be instructive for scientists developing nano-encapsulation and delivery systems and those focussing on tissue engineering and innovative cancer therapy applications.

TL;DR: In this article, a phenocopy resembling the hypomorphic poxn-phenotype was produced in embryos and larvae following induction of expression of alpha-Poxn2 intrabody.

TL;DR: A gene transfer strategy based on BBB‐crossing adeno‐associated virus (AAV)‐based vectors to deliver VHH directly into the central nervous system and demonstrates positive long‐term effects on amyloid load, neuroinflammation, synaptic function, and cognitive performance in the AppNL‐G‐F Alzheimer’s mouse model.

TL;DR: SPECT/μCT imaging with 99mTc-NbV4m119 allows specific assessment of inflammation in different arthritis models and provides complementary information to clinical scoring for quantitatively and non-invasively monitoring the pathological process and the efficacy of arthritis treatment.