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Sergei Chuikov
Researcher at Rutgers University
Publications - 7
Citations - 2795
Sergei Chuikov is an academic researcher from Rutgers University. The author has contributed to research in topics: Methylation & Histone methyltransferase. The author has an hindex of 6, co-authored 7 publications receiving 2642 citations. Previous affiliations of Sergei Chuikov include New York University & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Regulation of p53 activity through lysine methylation
Sergei Chuikov,Julia K. Kurash,Jonathan R. Wilson,Bing Xiao,Neil Justin,Gleb S. Ivanov,Kristine McKinney,Paul Tempst,Carol Prives,Steven J. Gamblin,Nickolai A. Barlev,Danny Reinberg +11 more
TL;DR: A novel mechanism of p53 regulation through lysine methylation by Set9 methyltransferase is reported, which specifically methylates p53 at one residue within the carboxyl-terminus regulatory region.
Journal ArticleDOI
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation
Kenichi Nishioka,Sergei Chuikov,Kavitha Sarma,Hediye Erdjument-Bromage,C. David Allis,Paul Tempst,Danny Reinberg +6 more
TL;DR: The results suggest that the methylation of histone tails can have distinct effects on transcription, depending on its chromosomal location, the combination of posttranslational modifications, and the enzyme (or protein complex) involved in the particular modification.
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PR-Set7 Is a Nucleosome-Specific Methyltransferase that Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin
Kenichi Nishioka,Judd C. Rice,Kavitha Sarma,Hediye Erdjument-Bromage,Janis Werner,Yanming Wang,Sergei Chuikov,Pablo Valenzuela,Paul Tempst,Ruth Steward,John T. Lis,C. David Allis,Danny Reinberg +12 more
TL;DR: The hypothesis that methylation of H4 lysine 20 maintains silent chromatin, in part, by precluding neighboring acetylation on the H4 tail is supported.
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TFIIH is negatively regulated by cdk8-containing mediator complexes
TL;DR: It is shown that cdk8/cyclin C can regulate transcription by targeting the cdk7/ cyclin H subunits of the general transcription initiation factor IIH (TFIIH), which links the Mediator complex and the basal transcription machinery by a regulatory pathway involving two cyclin-dependent kinases.
Journal ArticleDOI
G9a and Glp methylate lysine 373 in the tumor suppressor p53.
Jing Huang,Jing Huang,Jean Dorsey,Sergei Chuikov,Xinyue Zhang,Thomas Jenuwein,Thomas Jenuwein,Danny Reinberg,Danny Reinberg,Shelley L. Berger,Shelley L. Berger +10 more
TL;DR: Examination of the Oncomine data base shows that G9a and Glp are overexpressed in various cancers compared with corresponding normal tissues, suggesting that they are putative oncogenes and indicate that G 9a is a potential inhibitory target for cancer treatment.