S
Shanni N. Silberberg
Researcher at University of California, San Francisco
Publications - 10
Citations - 781
Shanni N. Silberberg is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Enhancer & Ganglionic eminence. The author has an hindex of 8, co-authored 9 publications receiving 635 citations.
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Journal ArticleDOI
A High-Resolution Enhancer Atlas of the Developing Telencephalon
Axel Visel,Axel Visel,Leila Taher,Hani Z. Girgis,Dalit May,Olga Golonzhka,Renée V. Hoch,Gabriel L. McKinsey,Kartik Pattabiraman,Shanni N. Silberberg,Matthew J. Blow,David V. Hansen,Alexander Nord,Jennifer A. Akiyama,Amy Holt,Roya Hosseini,Sengthavy Phouanenavong,Ingrid Plajzer-Frick,Malak Shoukry,Veena Afzal,Tommy Kaplan,Tommy Kaplan,Arnold R. Kriegstein,Edward M. Rubin,Edward M. Rubin,Ivan Ovcharenko,Len A. Pennacchio,Len A. Pennacchio,John L.R. Rubenstein +28 more
TL;DR: A digital atlas of in vivo enhancers active in subregions of the developing telencephalon, identifying more than 4,600 candidate embryonic forebrain enhancers and studying the in vivo activity of 329 of these sequences in transgenic mouse embryos is described.
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Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position.
Daniel Vogt,Robert F. Hunt,Shyamali Mandal,Shyamali Mandal,Magnus Sandberg,Shanni N. Silberberg,Takashi Nagasawa,Zhengang Yang,Scott C. Baraban,John L.R. Rubenstein +9 more
TL;DR: Using an in vivo MGE complementation/transplantation assay, it is demonstrated that some Lhx6⁻/⁻ MGE cells acquire a CGE-like fate and defines the molecular identity of LhX6 mutants and introduces technologies to test mechanisms in GABAergic interneuron differentiation.
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Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons
Magnus Sandberg,Pierre Flandin,Shanni N. Silberberg,Linda Su-Feher,J Price,Jia Sheng Hu,Carol Kim,Axel Visel,Axel Visel,Axel Visel,Alexander Nord,John L.R. Rubenstein +11 more
TL;DR: The integrated approach provides a foundation for elucidating transcriptional networks guiding the development of the MGE and its descendants by defining its chromosomal binding, regulation of gene expression, and epigenetic state.
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Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex
Kartik Pattabiraman,Olga Golonzhka,Susan Lindtner,Alexander Nord,Leila Taher,Renée V. Hoch,Shanni N. Silberberg,Dongji Zhang,Bin Chen,Hong Kui Zeng,Len A. Pennacchio,Luis Puelles,Axel Visel,John L.R. Rubenstein +13 more
TL;DR: Insight is provided into how broadly expressed patterning TFs regulate the activity of small enhancer elements that drive gene expression in pallial protodomains that fate map to distinct cortical regions.
Journal ArticleDOI
Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate
Shanni N. Silberberg,Leila Taher,Susan Lindtner,Magnus Sandberg,Alexander Nord,Alexander Nord,Alexander Nord,Daniel Vogt,Gabriel L. McKinsey,Renée V. Hoch,Kartik Pattabiraman,Dongji Zhang,José Luis Ferran,Aleksandar Rajkovic,Olga Golonzhka,Carol Kim,Hongkui Zeng,Luis Puelles,Axel Visel,Axel Visel,Axel Visel,John L.R. Rubenstein +21 more
TL;DR: Stable transgenic mouse lines that express CreERT2 and GFP from ten different enhancer elements with activity in distinct domains within the embryonic basal ganglia are generated to elucidate novel molecular mechanisms that regulate region-specific enhancer activity in the developing brain.