Kartik Pattabiraman

TL;DR: A digital atlas of in vivo enhancers active in subregions of the developing telencephalon, identifying more than 4,600 candidate embryonic forebrain enhancers and studying the in vivo activity of 329 of these sequences in transgenic mouse embryos is described.

TL;DR: A membrane-associated phosphoinositide cascade lies at the heart of the ipRGC phototransduction mechanism, similar to the cascade in rhabdomeric photoreceptors of invertebrate eyes, and reinforces the emerging view that these cells have a common evolutionary origin.

TL;DR: The current knowledge of how transcription factors drive gene expression programs through their interactions with cis-acting genomic elements, such as enhancers, is discussed; how analyses of chromatin and DNA modifications provide insights into gene expression states; and how these approaches yield insights into the evolution of the human brain.

TL;DR: Insight is provided into how broadly expressed patterning TFs regulate the activity of small enhancer elements that drive gene expression in pallial protodomains that fate map to distinct cortical regions.

TL;DR: Stable transgenic mouse lines that express CreERT2 and GFP from ten different enhancer elements with activity in distinct domains within the embryonic basal ganglia are generated to elucidate novel molecular mechanisms that regulate region-specific enhancer activity in the developing brain.