Susan Lindtner

TL;DR: It is demonstrated that the Zfhx1b (Sip1, Zeb2) zinc finger homeobox gene is required in the MGE, directly downstream of Dlx1&2, to generate cortical interneurons that express Cxcr7, MafB, and cMaf.

TL;DR: Insight is provided into how broadly expressed patterning TFs regulate the activity of small enhancer elements that drive gene expression in pallial protodomains that fate map to distinct cortical regions.

TL;DR: Stable transgenic mouse lines that express CreERT2 and GFP from ten different enhancer elements with activity in distinct domains within the embryonic basal ganglia are generated to elucidate novel molecular mechanisms that regulate region-specific enhancer activity in the developing brain.

TL;DR: The regulatory properties identified here for DLX TFs suggest general mechanisms by which TFs orchestrate dynamic expression programs underlying neurodevelopment, as well as explaining the paradox of widespread DLX binding contrasted with a limited subset of target loci that are sensitive at the epigenomic and transcriptomic level to Dlx1&2 ablation.

TL;DR: In this article, the authors showed that NPAS1 and NPAS3 transcription factors are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE).