S
Shaukat Khan
Researcher at Alfred I. duPont Hospital for Children
Publications - 41
Citations - 2006
Shaukat Khan is an academic researcher from Alfred I. duPont Hospital for Children. The author has contributed to research in topics: Medicine & Mucopolysaccharidosis. The author has an hindex of 17, co-authored 34 publications receiving 1682 citations. Previous affiliations of Shaukat Khan include Leiden University Medical Center & University of Minnesota.
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Journal ArticleDOI
Epidemiology of mucopolysaccharidoses
Shaukat Khan,Hira Peracha,Diana Ballhausen,Alfred Wiesbauer,Marianne Rohrbach,Matthias Gautschi,Robert W. Mason,Roberto Giugliani,Yasuyuki Suzuki,Kenji E. Orii,Tadao Orii,Shunji Tomatsu,Shunji Tomatsu,Shunji Tomatsu +13 more
TL;DR: Overall, the frequency of MPS varies for each population due to differences in ethnic backgrounds and/or founder effects that affect the birth prevalence of each type of M PS, as seen for other rare genetic diseases.
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Hematopoietic Stem Cell Transplantation for Mucopolysaccharidoses: Past, Present, and Future
Madeleine Taylor,Madeleine Taylor,Shaukat Khan,Molly Stapleton,Molly Stapleton,Jianmin Wang,Jing Chen,Robert Wynn,Hiromasa Yabe,Yasutsugu Chinen,Jaap Jan Boelens,Robert W. Mason,Robert W. Mason,Francyne Kubaski,Dafne Dain Gandelman Horovitz,Anneliese Lopes Barth,Marta Serafini,Maria Ester Bernardo,Hironori Kobayashi,Kenji E. Orii,Yasuyuki Suzuki,Tadao Orii,Shunji Tomatsu +22 more
TL;DR: The efficacy, side effects, risks, and cost of HSCT for each type of MPS is summarized.
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Systemic Correction of Storage Disease in MPS I NOD/SCID Mice Using the Sleeping Beauty Transposon System
Elena L. Aronovich,Jason B. Bell,Shaukat Khan,Shaukat Khan,Lalitha R. Belur,Roland Gunther,Brenda Koniar,Patricia A. Schachern,Josh B. Parker,Cathy S. Carlson,Chester B. Whitley,R. Scott McIvor,Pankaj Gupta,Pankaj Gupta,Perry B. Hackett +14 more
TL;DR: The SB transposon system proved efficacious in correcting several clinical manifestations of MPS I in mice, including thickening of the zygomatic arch, hepatomegaly, and accumulation of foamy macrophages in bone marrow and synovium, implying potential effectiveness of this approach in treatment of human MPSI.
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Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I.
Natalia Gomez-Ospina,Samantha G. Scharenberg,Nathalie Mostrel,Rasmus O. Bak,Sruthi Mantri,Rolen M. Quadros,Channabasavaiah B. Gurumurthy,Ciaran M. Lee,Gang Bao,Carlos Suárez,Shaukat Khan,Kazuki Sawamoto,Shunji Tomatsu,Nitin Raj,Laura D. Attardi,Laure Aurelian,Matthew H. Porteus +16 more
TL;DR: An efficient ex vivo genome editing approach using CRISPR-Cas9 that targets the lysosomal enzyme iduronidase to the CCR5 safe harbor locus in human CD34+ hematopoietic stem and progenitor cells is presented and can phenotypically correct MSPI in mouse model.
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Quantification of active and total transforming growth factor-β levels in serum and solid organ tissues by bioassay.
TL;DR: The bioassay demonstrated that both active and total tissue TGF-β levels were significantly higher in post-myocardial infarction than in sham myocardium, suggesting its high specificity to bioactive T GF-β.