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Ikuhiro Okamoto
Researcher at Kyoto University
Publications - 36
Citations - 5623
Ikuhiro Okamoto is an academic researcher from Kyoto University. The author has contributed to research in topics: X-inactivation & Embryonic stem cell. The author has an hindex of 19, co-authored 33 publications receiving 4336 citations. Previous affiliations of Ikuhiro Okamoto include PSL Research University & Curie Institute.
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Journal ArticleDOI
Spatial partitioning of the regulatory landscape of the X-inactivation centre
Elphège P. Nora,Bryan R. Lajoie,Edda G. Schulz,Luca Giorgetti,Luca Giorgetti,Luca Giorgetti,Ikuhiro Okamoto,Ikuhiro Okamoto,Ikuhiro Okamoto,Nicolas Servant,Nicolas Servant,Nicolas Servant,Tristan Piolot,Tristan Piolot,Tristan Piolot,Nynke L. van Berkum,Johannes Meisig,John W. Sedat,Joost Gribnau,Emmanuel Barillot,Emmanuel Barillot,Emmanuel Barillot,Nils Blüthgen,Job Dekker,Edith Heard,Edith Heard,Edith Heard +26 more
TL;DR: In addition to uncovering a new principle of cis-regulatory architecture of mammalian chromosomes, this study sets the stage for the full genetic dissection of the mouse X-inactivation centre.
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Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development
Ikuhiro Okamoto,Catherine Patrat,Dominique Thépot,Nathalie Peynot,Patricia Fauque,Nathalie Daniel,Patricia Diabangouaya,Jean-Philippe Wolf,Jean Paul Renard,Véronique Duranthon,Edith Heard +10 more
TL;DR: It is shown that other eutherian mammals have very different strategies for initiating XCI, and differences between mammals in their requirement for dosage compensation during early embryogenesis are highlighted.
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Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
Kotaro Sasaki,Shihori Yokobayashi,Tomonori Nakamura,Ikuhiro Okamoto,Yukihiro Yabuta,Kazuki Kurimoto,Hiroshi Ohta,Yoshinobu Moritoki,Yoshinobu Moritoki,Chizuru Iwatani,Hideaki Tsuchiya,Shinichiro Nakamura,Kiyotoshi Sekiguchi,Tetsushi Sakuma,Takashi Yamamoto,Takahide Mori,Knut Woltjen,Masato Nakagawa,Takuya Yamamoto,Kazutoshi Takahashi,Shinya Yamanaka,Mitinori Saitou +21 more
TL;DR: It is shown that human induced pluripotent stem cells differentiate into incipient mesoderm-like cells (iMeLCs), which robustly generate human primordial germ cell- like cells (hPGCLCs) that can be purified using the surface markers EpCAM and INTEGRINα6.
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A developmental coordinate of pluripotency among mice, monkeys and humans
Tomonori Nakamura,Ikuhiro Okamoto,Kotaro Sasaki,Yukihiro Yabuta,Chizuru Iwatani,Hideaki Tsuchiya,Yasunari Seita,Shinichiro Nakamura,Takuya Yamamoto,Mitinori Saitou +9 more
TL;DR: It is shown that after specification in the blastocysts, EPI from cynomolgus monkeys (cyEPI) undergoes major transcriptome changes on implantation, and, while generating gastrulating cells, cyEPI stably maintains its transcriptome over a week, retains a unique set of pluripotency genes and acquires properties for ‘neuron differentiation’.
Journal ArticleDOI
The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion
Kotaro Sasaki,Tomonori Nakamura,Ikuhiro Okamoto,Yukihiro Yabuta,Chizuru Iwatani,Hideaki Tsuchiya,Yasunari Seita,Shinichiro Nakamura,Naoto Shiraki,Tetsuya Takakuwa,Takuya Yamamoto,Mitinori Saitou +11 more
TL;DR: The authors showed that the SOX17/TFAP2C/BLIMP1-positive primordial germ cells (cyPGCs) originate from the dorsal amnion at embryonic day 11 (E11) prior to gastrulation.