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Shuang Chen
Researcher at Washington University in St. Louis
Publications - 9
Citations - 971
Shuang Chen is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Progenitor cell & Ureteric bud. The author has an hindex of 8, co-authored 9 publications receiving 847 citations. Previous affiliations of Shuang Chen include Pfizer & Cincinnati Children's Hospital Medical Center.
Papers
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Journal ArticleDOI
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.
Luca Pellegrinet,Verónica Rodilla,Zhenyi Liu,Shuang Chen,Ute Koch,Lluis Espinosa,Klaus H. Kaestner,Raphael Kopan,Julian Lewis,Freddy Radtke +9 more
TL;DR: Notch signaling inSCs and progenitors is activated by Dll1 and Dll4 ligands and is required for maintenance of intestinal progenitor and SCs and is dispensable for goblet cell differentiation in intestines of adult Notch-deficient mice.
Journal ArticleDOI
Fgf9 and FGF20 maintain the stemness of nephron progenitors in mice and man
Hila Barak,Sung Ho Huh,Shuang Chen,Cécile Jeanpierre,Cécile Jeanpierre,Jelena Martinovic,Mélanie Parisot,Christine Bole-Feysot,Patrick Nitschké,Rémi Salomon,Corinne Antignac,David M. Ornitz,Raphael Kopan +12 more
TL;DR: Findings identify a long-sought-after critical component of the nephron stem cell niche and hold promise for long-term culture and utilization of these progenitors in vitro.
Journal ArticleDOI
The Extracellular Domain of Notch2 Increases Its Cell-Surface Abundance and Ligand Responsiveness during Kidney Development
Zhenyi Liu,Shuang Chen,Scott Boyle,Yu Zhu,Andrew Zhang,David Piwnica-Worms,Ma. Xenia G. Ilagan,Raphael Kopan +7 more
TL;DR: It is found that the N2 extracellular domain (NECD) increases Notch protein localization to the cell surface during kidney development and is cleaved more efficiently upon ligand binding, resulting in context-specific asymmetry in NICD release efficiency.
Journal ArticleDOI
Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan
Shuang Chen,Eric W. Brunskill,S. Steven Potter,Phillip J. Dexheimer,Nathan Salomonis,Bruce J. Aronow,Christian I. Hong,Tongli Zhang,Raphael Kopan +8 more
TL;DR: Evidence is provided in support of a model in which intrinsic age-dependent changes affect inter-progenitor interactions that drive cessation of nephrogenesis, and single-cell transcriptome profiling revealed progressive age- dependent changes, with heterogeneity increasing in older populations.
Book ChapterDOI
Nephron Progenitor Cells: Shifting the Balance of Self-Renewal and Differentiation
TL;DR: In this article, the authors discuss the molecular processes allowing these populations to balance cell survival, self-renewal, support of branching, and maintain capacity to commit to differentiation within the developing mammalian kidney.