Y
Yi Zhou
Researcher at Florida State University
Publications - 72
Citations - 2727
Yi Zhou is an academic researcher from Florida State University. The author has contributed to research in topics: Induced pluripotent stem cell & Medicine. The author has an hindex of 29, co-authored 67 publications receiving 2220 citations. Previous affiliations of Yi Zhou include University of Alabama at Birmingham & University of Pennsylvania.
Papers
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Journal ArticleDOI
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
Liyan Qiao,Shusei Hamamichi,Kim A. Caldwell,Guy A. Caldwell,Talene A. Yacoubian,Scott M. Wilson,Zuo-Lei Xie,Lisa D Speake,Rachael Parks,Donna M. Crabtree,Qiuli Liang,Stephen L. Crimmins,Lonnie Schneider,Yasuo Uchiyama,Takeshi Iwatsubo,Yi Zhou,Lisheng Peng,YouMing Lu,David G. Standaert,Ken C. Walls,John J. Shacka,John J. Shacka,Kevin A. Roth,Jianhua Zhang +23 more
TL;DR: The data identify a conserved CD function in α-syn degradation and identify CD as a novel target for LB disease therapeutics.
Journal Article
14-3-3 proteins in neurological disorders
Molly Foote,Yi Zhou +1 more
TL;DR: Previous and more recent research is reviewed that has helped to understand the roles of 14-3-3 proteins in both neurodegenerative and neuropsychiatric diseases.
Journal ArticleDOI
A Dynamically Regulated 14–3–3, Slob, and Slowpoke Potassium Channel Complex in Drosophila Presynaptic Nerve Terminals
Yi Zhou,W.Michael Schopperle,Heather Murrey,Angela M. Jaramillo,Daniel Dagan,Leslie C. Griffith,Irwin B. Levitan +6 more
TL;DR: Evidence is provided for a dSlo/Slob/14-3-3 regulatory protein complex that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium (K(Ca) channel and dynamically regulated by calcium/calmodulin-dependent kinase II phosphorylation.
Journal ArticleDOI
Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.
Shu Yang,Miao Xu,Emily M. Lee,Kirill Gorshkov,Sergey A. Shiryaev,Shihua He,Wei Sun,Yu-Shan Cheng,Xin Hu,Anil Mathew Tharappel,Billy Lu,Antonella Pinto,Chen Farhy,Chun-Teng Huang,Zirui Zhang,Wenjun Zhu,Yuying Wu,Yi Zhou,Guang Song,Heng Zhu,Khalida Shamim,Carles Martínez-Romero,Adolfo García-Sastre,Richard A. Preston,Dushyantha Jayaweera,Ruili Huang,Wenwei Huang,Menghang Xia,Anton Simeonov,Guo Li Ming,Xiangguo Qiu,Xiangguo Qiu,Alexey V. Terskikh,Hengli Tang,Hongjun Song,Wei Zheng +35 more
TL;DR: It is shown that emetine, an anti-protozoal agent, potently inhibits ZIKV and EBOV infection with a low nanomolar half maximal inhibitory concentration (IC50) in vitro and potent activity in vivo.
Journal ArticleDOI
Slob, a Novel Protein that Interacts with the Slowpoke Calcium-Dependent Potassium Channel
W.Michael Schopperle,Holmqvist Mats Harald,Yi Zhou,Jing Wang,Zheng Wang,Leslie C. Griffith,Inna Keselman,Felicity Kusinitz,Daniel Dagan,Irwin B. Levitan +9 more
TL;DR: Confocal fluorescence microscopy demonstrates that Slob and dSlo redistribute in cotransfected cells and are colocalized in large intracellular structures, suggesting that they interact in vivo.