S
Silvia Speroni
Researcher at University of Pavia
Publications - 6
Citations - 339
Silvia Speroni is an academic researcher from University of Pavia. The author has contributed to research in topics: Flavivirus & RNA. The author has an hindex of 4, co-authored 4 publications receiving 290 citations.
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Journal ArticleDOI
Structure and functionality in flavivirus NS-proteins: Perspectives for drug design
Michela Bollati,Karin Alvarez,Rene Assenberg,Cécile Baronti,Bruno Canard,Shelley Cook,Bruno Coutard,Etienne Decroly,Xavier de Lamballerie,Ernest A. Gould,Gilda Grard,Jonathan M. Grimes,Rolf Hilgenfeld,Anna M. Jansson,Hélène Malet,Erika J. Mancini,Eloise Mastrangelo,Andrea Mattevi,Mario Milani,Gregory Moureau,Johan Neyts,Raymond J. Owens,Jingshan Ren,Barbara Selisko,Silvia Speroni,Holger Steuber,David I. Stuart,Torsten Unge,Martino Bolognesi +28 more
TL;DR: Structural and functional aspects emerging from the characterization of two main components (NS3 and NS5 proteins) of the flavivirus replication complex are reviewed to shed light on the design and development of antiviral drug leads.
Journal ArticleDOI
Structural and biochemical analysis of human pathogenic astrovirus serine protease at 2.0 A resolution.
Silvia Speroni,Jacques Rohayem,Simone Nenci,Daniele Bonivento,Ivonne Robel,Julia Barthel,Victor B. Luzhkov,Bruno Coutard,Bruno Canard,Andrea Mattevi +9 more
TL;DR: The comparative structural analysis highlights the peculiarity of the astrovirus protease, and differentiates it from the human and viral serine proteases.
Journal ArticleDOI
Structure and biochemical analysis of Kokobera virus helicase
Silvia Speroni,Luigi De Colibus,Eloise Mastrangelo,Ernest A. Gould,Bruno Coutard,Naomi L. Forrester,Séverine Blanc,Bruno Canard,Andrea Mattevi +8 more
TL;DR: Structure and biochemical analysis of Kokobera virus helicase and its role in infectious disease and fungal pathogenesis are studied.
Journal ArticleDOI
Purification and crystallization of Kokobera virus helicase
Luigi De Colibus,Silvia Speroni,Bruno Coutard,Naomi L. Forrester,Ernest A. Gould,Bruno Canard,Andrea Mattevi +6 more
TL;DR: Crystals of the Kokobera virus helicase domain were obtained by the hanging-drop vapour-diffusion method and belong to space group P3(1)21 (or P3 (2)21), with unit-cell parameters a = 88.6, c = 138.6 A, and exhibit a diffraction limit of 2.3 A.
Posted ContentDOI
APC couples neuronal mRNAs to multiple kinesins, EB1, and shrinking microtubule ends for bidirectional mRNA motility
Sebastian Baumann,Julia Grawenhoff,Elsa C. Rodrigues,Silvia Speroni,Maria Gili,Artem Komissarov,Sebastian Maier +6 more
TL;DR: These findings establish APC as a versatile mRNA-kinesin adaptor and a key factor for the assembly and bidirectional movement of neuronal transport mRNPs.