Eloise Mastrangelo

TL;DR: Ivermectin, a broadly used anti-helminthic drug, proved to be a highly potent inhibitor of YFV replication and inhibited, although less efficiently, the replication of several other flaviviruses, i.e. dengue fever, Japanese encephalitis and tick-borne encephalopathy viruses.

TL;DR: Structural and functional aspects emerging from the characterization of two main components (NS3 and NS5 proteins) of the flavivirus replication complex are reviewed to shed light on the design and development of antiviral drug leads.

TL;DR: The crystal structure of full-length Murray Valley encephalitis virus NS3 fused with the protease activation peptide of NS2B reveals a relative orientation of the two domains that is radically different between the two structures, suggesting that the relative domain-domain orientation in NS3 is highly variable and dictated by a flexible interdomain linker.

TL;DR: Molecular and clinical aspects of filoviral haemorrhagic fevers are summarized and vaccine appears the unique therapeutic frontier.

TL;DR: The crystal structure of MNV RdRp alone and in the presence of the two identified inhibitors is reported, hinting at a conserved inhibitor binding mode in the two polymerases.