S
Simon A. Forbes
Researcher at Wellcome Trust Sanger Institute
Publications - 61
Citations - 27323
Simon A. Forbes is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: COSMIC cancer database & Cancer. The author has an hindex of 36, co-authored 59 publications receiving 22292 citations. Previous affiliations of Simon A. Forbes include Imperial College London & Howard Hughes Medical Institute.
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Journal ArticleDOI
Patterns of somatic mutation in human cancer genomes
Christopher Greenman,Philip J. Stephens,Raffaella Smith,Gillian L. Dalgliesh,Christopher I. Hunter,Graham R. Bignell,Helen Davies,Jon W. Teague,Adam Butler,Claire Stevens,Sarah Edkins,Sarah O’Meara,Imre Vastrik,Esther Schmidt,Tim Avis,Syd Barthorpe,Gurpreet Bhamra,Gemma Buck,Bhudipa Choudhury,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kris Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jon Hinton,Andy Jenkinson,David T. Jones,Andy Menzies,Tatiana Mironenko,Janet Perry,Keiran Raine,Dave Richardson,Rebecca Shepherd,Alexandra Small,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Daniel P. Cahill,David N. Louis,Peter Goldstraw,Andrew G. Nicholson,Francis Brasseur,Leendert H. J. Looijenga,Barbara L. Weber,Yoke Eng Chiew,Anna deFazio,Mel Greaves,Anthony R. Green,Peter J. Campbell,Ewan Birney,Douglas F. Easton,Georgia Chenevix-Trench,Min-Han Tan,Sok Kean Khoo,Bin Tean Teh,Siu Tsan Yuen,Suet Yi Leung,Richard Wooster,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +66 more
TL;DR: More than 1,000 somatic mutations found in 274 megabases of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers reveal the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
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COSMIC: the Catalogue Of Somatic Mutations In Cancer
John Tate,Sally Bamford,Harry Jubb,Harry Jubb,Zbyslaw Sondka,David Beare,Nidhi Bindal,Harry Boutselakis,Charlotte G. Cole,Celestino Creatore,Elisabeth Dawson,Peter Fish,Bhavana Harsha,Charlie Hathaway,Steve C Jupe,Chai Yin Kok,Kate Noble,Laura Ponting,Christopher C Ramshaw,Claire Rye,Helen E. Speedy,Raymund Stefancsik,Sam Thompson,Shicai Wang,Sari Ward,Peter J. Campbell,Simon A. Forbes +26 more
TL;DR: Improvements to the public website and data-download systems and new functionality in COSMIC-3D allows exploration of mutations within three-dimensional protein structures, their protein structural and functional impacts, and implications for druggability.
Journal ArticleDOI
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer.
Simon A. Forbes,Nidhi Bindal,Sally Bamford,Charlotte G. Cole,Chai Yin Kok,David Beare,Mingming Jia,Rebecca Shepherd,Kenric Leung,Andrew Menzies,Jon W. Teague,Peter J. Campbell,Michael R. Stratton,P. Andrew Futreal +13 more
TL;DR: With all genomic information recently updated to GRCh37, COSMIC integrates many diverse types of mutation information and is making much closer links with Ensembl and other data resources.
Journal ArticleDOI
COSMIC: exploring the world's knowledge of somatic mutations in human cancer
Simon A. Forbes,David Beare,Prasad Gunasekaran,Kenric Leung,Nidhi Bindal,Harry Boutselakis,Minjie Ding,Sally Bamford,Charlotte G. Cole,Sari Ward,Chai Yin Kok,Mingming Jia,Tisham De,Jon W. Teague,Michael R. Stratton,Ultan McDermott,Peter J. Campbell +16 more
TL;DR: COSMIC, the Catalogue Of Somatic Mutations In Cancer is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer, describing 2 002 811 coding point mutations in over one million tumor samples and across most human genes.
Journal ArticleDOI
Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells
Wanjuan Yang,Jorge Soares,Patricia Greninger,Elena J. Edelman,Howard Lightfoot,Simon A. Forbes,Nidhi Bindal,Dave Beare,James Smith,I. Richard Thompson,Sridhar Ramaswamy,P. Andrew Futreal,Daniel A. Haber,Michael R. Stratton,Cyril H. Benes,Ultan McDermott,Mathew J. Garnett +16 more
TL;DR: The Genomics of Drug Sensitivity in Cancer (GDSC) provides a unique resource incorporating large drug sensitivity and genomic datasets to facilitate the discovery of new therapeutic biomarkers for cancer therapies.