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Bhudipa Choudhury
Researcher at Wellcome Trust Sanger Institute
Publications - 3
Citations - 3261
Bhudipa Choudhury is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Germline mutation. The author has an hindex of 3, co-authored 3 publications receiving 3081 citations.
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Journal ArticleDOI
Patterns of somatic mutation in human cancer genomes
Christopher Greenman,Philip J. Stephens,Raffaella Smith,Gillian L. Dalgliesh,Christopher I. Hunter,Graham R. Bignell,Helen Davies,Jon W. Teague,Adam Butler,Claire Stevens,Sarah Edkins,Sarah O’Meara,Imre Vastrik,Esther Schmidt,Tim Avis,Syd Barthorpe,Gurpreet Bhamra,Gemma Buck,Bhudipa Choudhury,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kris Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jon Hinton,Andy Jenkinson,David T. Jones,Andy Menzies,Tatiana Mironenko,Janet Perry,Keiran Raine,Dave Richardson,Rebecca Shepherd,Alexandra Small,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Daniel P. Cahill,David N. Louis,Peter Goldstraw,Andrew G. Nicholson,Francis Brasseur,Leendert H. J. Looijenga,Barbara L. Weber,Yoke Eng Chiew,Anna deFazio,Mel Greaves,Anthony R. Green,Peter J. Campbell,Ewan Birney,Douglas F. Easton,Georgia Chenevix-Trench,Min-Han Tan,Sok Kean Khoo,Bin Tean Teh,Siu Tsan Yuen,Suet Yi Leung,Richard Wooster,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +66 more
TL;DR: More than 1,000 somatic mutations found in 274 megabases of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers reveal the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
Journal ArticleDOI
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
Richard S. Maser,Bhudipa Choudhury,Peter J. Campbell,Bin Feng,Kwok-Kin Wong,Alexei Protopopov,Jennifer O'Neil,Alejandro Gutierrez,Elena Ivanova,Ilana Perna,Eric Lin,Vidya Mani,Shan Jiang,Kate McNamara,Sara Zaghlul,Sarah Edkins,Claire Stevens,Cameron Brennan,Eric S. Martin,Ruprecht Wiedemeyer,Omar Kabbarah,Cristina W. Nogueira,Gavin Histen,Jon C. Aster,Marc R. Mansour,Veronique Duke,Letizia Foroni,Adele K. Fielding,Anthony H. Goldstone,Jacob M. Rowe,Yaoqi A. Wang,A. Thomas Look,Michael R. Stratton,Lynda Chin,P. Andrew Futreal,Ronald A. DePinho +35 more
TL;DR: The results indicate that murine and human tumours experience common biological processes driven by orthologous genetic events in their malignant evolution.
Journal ArticleDOI
LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition
C L Mahoney,Bhudipa Choudhury,Helen Davies,Sarah Edkins,Christopher Greenman,G van Haaften,Tatiana Mironenko,Thomas Santarius,Claire Stevens,Michael R. Stratton,P A Futreal +10 more
TL;DR: The data suggest that LKB1/KRAS mutant NSCLCs are a genetically and functionally distinct subset and further suggest that this subset of lung cancers might afford an opportunity for exploitation of anti-MAPK/mTOR-targeted therapies.