CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
Ivan Zanoni,Renato Ostuni,Lorri R. Marek,Simona Barresi,Roman Barbalat,Gregory M. Barton,Francesca Granucci,Jonathan C. Kagan +7 more
TLDR
It is reported that the plasma membrane localized Pattern Recognition Receptor (PRR) CD14 is required for the microbe-induced endocytosis of TLR4, and this innate immune trafficking cascade illustrates how pathogen detection systems operate to induce both membrane transport and signal transduction.About:
This article is published in Cell.The article was published on 2011-11-11 and is currently open access. It has received 785 citations till now. The article focuses on the topics: Endocytosis & Endocytosis Pathway.read more
Citations
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Journal ArticleDOI
Toll-like receptor signaling pathways.
Takumi Kawasaki,Taro Kawai +1 more
TL;DR: Recent progress is described in the understanding of TLR signaling regulation and its contributions to host defense.
Journal ArticleDOI
Innate immune pattern recognition: a cell biological perspective.
TL;DR: This review highlights aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol.
Journal ArticleDOI
Toll-like Receptors and the Control of Immunity.
TL;DR: The mechanisms and consequences of TLR-mediated signal transduction are described with a focus on themes identified in the TLR pathways that also explain the operation of other immune signaling pathways.
Journal ArticleDOI
High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
Dunja Mrdjen,Anto Pavlovic,Felix J. Hartmann,Bettina Schreiner,Sebastian G. Utz,Brian P. Leung,Iva Lelios,Frank L. Heppner,Jonathan Kipnis,Doron Merkler,Melanie Greter,Burkhard Becher +11 more
TL;DR: High‐dimensional cytometry reveals that microglia, several subsets of border‐associated macrophages and dendritic cells coexist in the CNS at steady state and exhibit disease‐specific transformations in the immune microenvironment during aging and in models of Alzheimer’s disease and multiple sclerosis.
Journal ArticleDOI
Assembly and localization of Toll-like receptor signalling complexes
TL;DR: The molecular basis for the recognition of pathogen-associated molecular patterns, the nature of the protein complexes that mediate signalling, and the way in which signals are regulated and integrated at the level of allosteric assembly, post-translational modification and subcellular trafficking of the components of the signalling complexes are discussed.
References
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Journal ArticleDOI
Toll-like receptor signalling
Shizuo Akira,Kiyoshi Takeda +1 more
TL;DR: Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed.
Journal ArticleDOI
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
Journal ArticleDOI
A Toll-like receptor recognizes bacterial DNA.
Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira +10 more
TL;DR: It is shown that cellular response to CpG DNA is mediated by a Toll-like receptor, TLR9, and vertebrate immune systems appear to have evolved a specific Toll- like receptor that distinguishes bacterial DNA from self-DNA.
Journal ArticleDOI
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.
TL;DR: CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha by whole blood incubated with LPS.
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