S
Simonas Savickas
Researcher at Technical University of Denmark
Publications - 13
Citations - 300
Simonas Savickas is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 7, co-authored 10 publications receiving 127 citations. Previous affiliations of Simonas Savickas include Harvard University & ETH Zurich.
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Journal ArticleDOI
Quantitative single-cell proteomics as a tool to characterize cellular hierarchies.
Erwin M. Schoof,Benjamin Furtwängler,Nil Üresin,Nicolas Rapin,Simonas Savickas,Coline Gentil,Eric R. Lechman,Eric R. Lechman,Ulrich auf dem Keller,John E. Dick,John E. Dick,Bo T. Porse +11 more
TL;DR: In this article, a global single-cell mass spectrometry-based proteomics approach is proposed for large-scale single cell analyses, which can provide insights into the molecular basis for cellular heterogeneity.
Journal ArticleDOI
Comparative Degradomics of Porcine and Human Wound Exudates Unravels Biomarker Candidates for Assessment of Wound Healing Progression in Trauma Patients.
Fabio Sabino,Fabio Sabino,Fabian E. Egli,Simonas Savickas,Jörg H. Holstein,D. Kaspar,Mika F. Rollmann,Jayachandran N. Kizhakkedathu,Jayachandran N. Kizhakkedathu,Tim Pohlemann,Hans Smola,Ulrich auf dem Keller,Ulrich auf dem Keller +12 more
TL;DR: The possibility of using a fine-tuned animal wound model to bridge the translational gap as a prerequisite for future extended clinical studies with large cohorts of individuals affected by healing impairments is shown.
Journal ArticleDOI
ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control
TL;DR: It is shown that ELAC1 is both necessary and sufficient to remove the 2',3'-cyclic phosphate on ANKZF1-cleaved tRNAs to permit CCA re-addition by TRNT1.
Posted ContentDOI
A Quantitative Single-Cell Proteomics Approach to Characterize an Acute Myeloid Leukemia Hierarchy
Erwin M. Schoof,Nicolas Rapin,Simonas Savickas,Coline Gentil,Eric R. Lechman,Eric R. Lechman,James Haile,dem Keller Ua,John E. Dick,John E. Dick,Bo T. Porse +10 more
TL;DR: An experimental and computational pipeline is presented, which establishes a comprehensive single-cell mass spectrometry-based proteomics workflow and develops a computational pipeline, that effectively clusters the data and permits the extraction of cell-specific proteins and functional pathways.
Journal ArticleDOI
Targeted degradomics in protein terminomics and protease substrate discovery.
TL;DR: The general principles of targeted degradomics are described, the generic experimental workflow of the methodology is outlined, and recent and future applications in protease research are highlighted.