Simone Rampelli

TL;DR: It is shown that the Hadza have higher levels of microbial richness and biodiversity than Italian urban controls, and enrichment in Prevotella, Treponema and unclassified Bacteroidetes, as well as a peculiar arrangement of Clostridiales taxa, may enhance the hadza’s ability to digest and extract valuable nutrition from fibrous plant foods.

TL;DR: This work provides for the first time the phylogenetic microbiota analysis of semi-supercentenarians, i.e., 105-109 years old, in comparison to adults, elderly, and centenarian, thus reconstructing the longest available human microbiota trajectory along aging.

TL;DR: The findings support the feasibility of improving the habitual diet to modulate the gut microbiota which in turn has the potential to promote healthier ageing.

TL;DR: The first metagenomic analysis of GM from Hadza hunter-gatherers of Tanzania shows a unique enrichment in metabolic pathways that aligns with the dietary and environmental factors characteristic of their foraging lifestyle, providing a better understanding of the versatility of human life and subsistence.

TL;DR: The data emphasize the relationship between intestinal bacteria and human metabolism, by detailing the modifications in the gut microbiota as a consequence of and/or promoter of the physiological changes occurring in the human host upon ageing.