S
Soonjeon Youn
Researcher at Washington University in St. Louis
Publications - 13
Citations - 1454
Soonjeon Youn is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Viral replication & Virus. The author has an hindex of 10, co-authored 13 publications receiving 1270 citations. Previous affiliations of Soonjeon Youn include Johns Hopkins University School of Medicine & Texas A&M University.
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Journal ArticleDOI
2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members
Stephane Daffis,Kristy J. Szretter,Jill Schriewer,Jianqing Li,Soonjeon Youn,John S. Errett,Tsai-Yu Lin,Stewart W. Schneller,Roland Züst,Hongping Dong,Volker Thiel,Volker Thiel,Ganes C. Sen,Volker Fensterl,William B. Klimstra,Theodore C. Pierson,R. Mark L. Buller,Michael Gale,Pei Yong Shi,Michael S. Diamond +19 more
TL;DR: It is demonstrated that a West Nile virus mutant that lacks 2′-O MTase activity was attenuated in wild-type primary cells and mice but was pathogenic in the absence of type I interferon (IFN) signalling, and suggested an evolutionary explanation for 2-O methylation of cellular mRNA: to distinguish self from non-self RNA.
Journal ArticleDOI
Antagonism of the complement component C4 by flavivirus nonstructural protein NS1
Panisadee Avirutnan,Anja Fuchs,Richard E. Hauhart,Pawit Somnuke,Pawit Somnuke,Soonjeon Youn,Michael S. Diamond,John P. Atkinson +7 more
TL;DR: This work demonstrates that dengue virus, West Nile virus, and yellow fever virus NS1 attenuate classical and lectin pathway activation by directly interacting with C4, and defines a novel immune evasion mechanism for restricting complement control of microbial infection.
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Evidence for a Genetic and Physical Interaction between Nonstructural Proteins NS1 and NS4B That Modulates Replication of West Nile Virus
Soonjeon Youn,Tuo Li,Broc T. McCune,Melissa A. Edeling,Daved H. Fremont,Ileana M. Cristea,Michael S. Diamond +6 more
TL;DR: A suppressor mutation (F86C) in NS4B, a virally encoded transmembrane protein with loops on both the luminal and cytoplasmic sides of the ER membrane is identified, suggesting a mechanism for how luminal NS1 conveys signals to the cy toplasm to regulate RNA replication.
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In vitro assembled, recombinant infectious bronchitis viruses demonstrate that the 5a open reading frame is not essential for replication.
TL;DR: It is demonstrated that the 5a ORF is not essential for viral multiplication in Vero cells and that the MIBV demonstrated growth kinetics and plaque size and morphology that resembled the parental Beaudette strain IBV.
Journal ArticleDOI
A Short N-Terminal Peptide Motif on Flavivirus Nonstructural Protein NS1 Modulates Cellular Targeting and Immune Recognition
TL;DR: The requirements for cellular targeting of NS1 are defined, with implications for the protective host responses, immune antagonism, and association with the host cell sorting machinery, and a link between the effects of NS 1 on viral replication and the levels of secreted or cell surface NS1 is suggested.