S
Sourav Banerjee
Researcher at University of Dundee
Publications - 18
Citations - 786
Sourav Banerjee is an academic researcher from University of Dundee. The author has contributed to research in topics: Kinase & Phosphorylation. The author has an hindex of 8, co-authored 18 publications receiving 558 citations. Previous affiliations of Sourav Banerjee include University of California, San Diego.
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Journal ArticleDOI
New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.
Anna Zagórska,Maria Deak,David G. Campbell,Sourav Banerjee,Mariko Hirano,Shinichi Aizawa,Alan R. Prescott,Dario R. Alessi +7 more
TL;DR: A new function for LKB1 is defined in decreasing cell adhesion through inhibition of myosin phosphatase activity and indicate that NUAK1 may contribute to tumor invasion by activating cytoskeletal motor proteins and thereby promoting cell detachment.
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Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis
TL;DR: It is shown that the proteasome is dynamically phosphorylated during the cell cycle at Thr 25 of the 19S subunit Rpt3, and dual-specificity tyrosine-regulated kinase 2 (DYRK2) is the primary kinase that phosphorylates Rpt 3-Thr25, leading to enhanced substrate translocation and degradation.
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Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2
Sourav Banerjee,Chenggong Ji,Joshua E. Mayfield,Apollina Goel,Junyu Xiao,Jack E. Dixon,Xing Guo +6 more
TL;DR: Curcumin perturbs 26S proteasome activity via DYRK2 inhibition in various cancer cells and in the mouse cancer model leading to impairment of cell proliferation and reduction of cancer burden in mice, revealing an unexpected role of curcumin in DyrK2-proteasome inhibition.
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Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas
Jelena Todoric,Jelena Todoric,Laura Antonucci,Giuseppe Di Caro,Ning Li,Xuefeng Wu,Nikki K. Lytle,Debanjan Dhar,Sourav Banerjee,Johan Bourghardt Fagman,Cecille D. Browne,Atsushi Umemura,Atsushi Umemura,Mark A. Valasek,Hannes Kessler,David Tarin,Michael Goggins,Tannishtha Reya,Maria T. Diaz-Meco,Jorge Moscat,Michael Karin +20 more
TL;DR: It is shown that accumulation of the autophagy substrate p62/SQSTM1 in stressed KrasG12D acinar cells is associated with PDAC development and maintenance of malignancy in human cells and mice and that MDM2 targeting may be useful for preventingPDAC development in high-risk individuals.
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Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases
Sourav Banerjee,Sara J. Buhrlage,Hai-Tsang Huang,Xianming Deng,Wenjun Zhou,Jinhua Wang,Ryan Traynor,Alan R. Prescott,Dario R. Alessi,Nathanael S. Gray +9 more
TL;DR: The results of the present study indicate that WZ4003 and HTH-01-015 will serve as useful chemical probes to delineate the biological roles of the NUAK kinases.