S
Stephanie Gamez
Researcher at University of California, San Diego
Publications - 30
Citations - 780
Stephanie Gamez is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Population & Aedes aegypti. The author has an hindex of 11, co-authored 30 publications receiving 435 citations. Previous affiliations of Stephanie Gamez include University of California, Riverside & University of California, Berkeley.
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Journal ArticleDOI
Development of a confinable gene drive system in the human disease vector Aedes aegypti
Ming Li,Ting Yang,Nikolay P. Kandul,Michelle Bui,Stephanie Gamez,Robyn R. Raban,Jared B. Bennett,M C Héctor Sánchez,Gregory C. Lanzaro,Hanno Schmidt,Yoosook Lee,John M. Marshall,Omar S. Akbari +12 more
TL;DR: Several CRISPR-based split gene drives are developed for use in Ae.
Journal ArticleDOI
Engineered resistance to Zika virus in transgenic Aedes aegypti expressing a polycistronic cluster of synthetic small RNAs.
Anna Buchman,Stephanie Gamez,Ming Li,Igor Antoshechkin,Hsing-Han Li,Hsin-Wei Wang,Chun-Hong Chen,Melissa J. Klein,Jean-Bernard Duchemin,Prasad N. Paradkar,Omar S. Akbari +10 more
TL;DR: The generation of Aedes aegypti mosquitoes that are engineered to be resistant to Zika virus (ZIKV) transmission is described, and a polycistronic cluster of engineered synthetic small RNAs targeting ZIKV is demonstrated, ensuring the formation of mature synthetic smallRNAs in the midgut where ZikV resides in the early stages of infection.
Journal ArticleDOI
Improved reference genome of the arboviral vector Aedes albopictus.
Umberto Palatini,Reem A. Masri,Luciano V. Cosme,Sergey Koren,Françoise Thibaud-Nissen,James K. Biedler,Flavia Krsticevic,J. Spencer Johnston,Rebecca Halbach,Jacob E. Crawford,Igor Antoshechkin,Anna-Bella Failloux,Elisa Pischedda,Michele Marconcini,Jay Ghurye,Arang Rhie,Atashi Sharma,D. A. Karagodin,Jeremy Jenrette,Stephanie Gamez,Pascal Miesen,Patrick Masterson,Adalgisa Caccone,Maria V. Sharakhova,Maria V. Sharakhova,Maria V. Sharakhova,Zhijian Tu,Philippos Aris Papathanos,Ronald P. van Rij,Omar S. Akbari,Jeffrey R. Powell,Adam M. Phillippy,Mariangela Bonizzoni +32 more
TL;DR: This work uses long-read sequencing methods and modern scaffolding techniques to produce AalbF2, a dramatically improved assembly of the Ae.
Journal ArticleDOI
Broad Dengue Neutralization in Mosquitoes Expressing an Engineered Antibody
Anna Buchman,Stephanie Gamez,Ming Li,Igor Antoshechkin,Hsing-Han Li,Hsing-Han Li,Hsing-Han Li,Hsin-Wei Wang,Hsin-Wei Wang,Chun-Hong Chen,Chun-Hong Chen,Melissa J. Klein,Jean-Bernard Duchemin,James E. Crowe,Prasad N. Paradkar,Omar S. Akbari +15 more
TL;DR: These mosquitoes express a gene encoding an engineered single-chain variable fragment derived from a broadly neutralizing DENV human monoclonal antibody and have significantly reduced viral infection, dissemination, and transmission rates for all four major antigenically distinct DENV serotypes.
Posted ContentDOI
Development of a Confinable Gene-Drive System in the Human Disease Vector, Aedes aegypti.
Ming Li,Ting Yang,Nikolay P. Kandul,Michelle Bui,Stephanie Gamez,Robyn R. Raban,Jared B. Bennett,M C Héctor Sánchez,Gregory C. Lanzaro,Hanno Schmidt,Yoosook Lee,John M. Marshall,Omar S. Akbari +12 more
TL;DR: Several CRISPR-based split-gene drives are engineered and tested and provide compelling path forward for the feasibility of future effector-linked split-drive technologies that can contribute to the safe, sustained control and potentially the elimination of pathogens transmitted by this species.