Stephen B. Lewis

TL;DR: It is demonstrated that sequencing of densely affected families permits exploration of the role of rare variants in a relatively common disease such as IA, although there are important study design considerations for applying sequencing to complex disorders.

TL;DR: Levels of spectrin breakdown products (SBDPs) in cerebrospinal fluid (CSF) from adults with severe TBI are examined and the relationship between these levels, severity of injury, and clinical outcome is examined.

TL;DR: With appropriate attention to surgical technique, a saphenous vein extracranial-to-intracranian bypass followed by acute parent vessel occlusion is a safe and effective method of treating giant intracranial aneurysms.

TL;DR: Despite a shorter length of hospitalization in patients with unruptured aneurysms, coiling was associated with higher hospital costs in both patients withunruptured and rupturedAneurysm clipping, and this is likely attributable to the higher device cost of coils than clips.

TL;DR: In a case-control study of patients with multiple cerebral aneurysms, increased bottleneck factor and height-width ratio were consistently associated with rupture as discussed by the authors, and they were the only measures that were significantly predictive of rupture.