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Stephen H. Bartelmez
Researcher at University of Washington
Publications - 22
Citations - 2962
Stephen H. Bartelmez is an academic researcher from University of Washington. The author has contributed to research in topics: Progenitor cell & Stem cell. The author has an hindex of 11, co-authored 21 publications receiving 2900 citations. Previous affiliations of Stephen H. Bartelmez include University of Florida.
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Journal ArticleDOI
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Charles E. Murry,Mark H. Soonpaa,Hans Reinecke,Hidehiro Nakajima,Hisako O. Nakajima,Michael Rubart,Kishore B.S. Pasumarthi,Kishore B.S. Pasumarthi,Jitka A. I. Virag,Stephen H. Bartelmez,Veronica Poppa,Gillian Bradford,Joshua D. Dowell,David A. Williams,David A. Williams,Loren J. Field +15 more
TL;DR: Results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair.
Journal ArticleDOI
Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells.
TL;DR: It is shown that the continuous presence of TGF-beta 1 directly inhibits the cell division of essentially all low Ho/Rh cells during their 0 to 5th cell division in vitro, which must directly inhibit the proliferation of LTR-HSC contained within these low Ho-Rh cells.
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Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin.
TL;DR: The results demonstrate that TPO can mediate the self-replication of HSC in LTBMC, and provide proof that HSC can self-Replication ex vivo.
Journal ArticleDOI
Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth
Jonathan R. Keller,Stephen H. Bartelmez,Ewa Sitnicka,Francis W. Ruscetti,Mariaestella Ortiz,John Gooya,Sten Eirik W. Jacobsen +6 more
TL;DR: MIP-1 alpha and TGF beta are direct bidirectional regulators of HPC growth, whose effects are dependent on other growth factors present as well as the maturational state of the HPC assayed.
Journal ArticleDOI
Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model
Sugata Hazra,Yagna P. R. Jarajapu,Valerie Stepps,Sergio Caballero,Jeffrey S. Thinschmidt,Laura Sautina,N. Bengtsson,S. LiCalzi,James M. Dominguez,Timothy S. Kern,Mark S. Segal,John D. Ash,Daniel R. Saban,Stephen H. Bartelmez,Maria B. Grant +14 more
TL;DR: The BM microenvironment of type 1 diabetic mice can lead to changes in haematopoiesis, with generation of more monocytes and fewer EPCs contributing to development of microvascular complications and inhibition of GP130 activation may serve as a therapeutic strategy to improve the key aspects of this dysfunction.