Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model
Sugata Hazra,Yagna P. R. Jarajapu,Valerie Stepps,Sergio Caballero,Jeffrey S. Thinschmidt,Laura Sautina,N. Bengtsson,S. LiCalzi,James M. Dominguez,Timothy S. Kern,Mark S. Segal,John D. Ash,Daniel R. Saban,Stephen H. Bartelmez,Maria B. Grant +14 more
Reads0
Chats0
TLDR
The BM microenvironment of type 1 diabetic mice can lead to changes in haematopoiesis, with generation of more monocytes and fewer EPCs contributing to development of microvascular complications and inhibition of GP130 activation may serve as a therapeutic strategy to improve the key aspects of this dysfunction.Abstract:
Aims/hypothesis
We sought to determine the impact of long-standing type 1 diabetes on haematopoietic stem/progenitor cell (HSC) number and function and to examine the impact of modulating glycoprotein (GP)130 receptor in these cells.read more
Citations
More filters
Journal ArticleDOI
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2.
Mahmoud Gheblawi,Kaiming Wang,Anissa Viveiros,Quynh Nguyen,Jiu Chang Zhong,Anthony J. Turner,Mohan K. Raizada,Maria B. Grant,Gavin Y. Oudit +8 more
TL;DR: A review summarizes the progress over the past 20 years, highlighting the critical role of ACE2 as the novel SARS-CoV-2 receptor and as the negative regulator of the renin-angiotensin system, together with implications for the coronavirus disease 2019 pandemic and associated cardiovascular diseases.
Journal ArticleDOI
The Role of Inflammation in Diabetic Retinopathy
TL;DR: The relationship between early leukocytes activation and the later features of DR are discussed, common pathogenetic processes between diabetic microvascular disease and other vascular retinopathies, the mechanisms whereby leukocyte activation is induced in hyperglycemia and dyslipidemia, the signaling mechanisms involved in diabetic microVascular disease, and possible interventions which may prevent these retInopathies.
Journal ArticleDOI
Diabetes Mellitus and Ischemic Diseases Molecular Mechanisms of Vascular Repair Dysfunction
TL;DR: An overview of the current understanding on the signaling molecules contributing to the diabetes mellitus–induced impairment of postischemic revascularization mainly in the setting of myocardial infarction or critical limb ischemia is given.
Journal ArticleDOI
Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity
TL;DR: Long-term high glucose sensitizes macrophages to cytokine stimulation and reduces phagocytosis and nitric oxide production, which may be related to impaired glycolytic capacity.
Journal ArticleDOI
Microglia and Monocyte-Derived Macrophages in Stroke
Eunhee Kim,Sunghee Cho +1 more
TL;DR: A role for microglia and monocytes/macrophages in acute ischemic stroke in the context of normal and metabolically compromised conditions is summarized.
References
More filters
Journal ArticleDOI
Isolation of putative progenitor endothelial cells for angiogenesis.
Takayuki Asahara,Toyoaki Murohara,Alison Sullivan,Marcy Silver,Rien van der Zee,Tong Li,Bernhard Witzenbichler,Gina C. Schatteman,Jeffrey M. Isner +8 more
TL;DR: It is suggested that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarianAngiogenesis.
Journal ArticleDOI
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Karen Bedard,Karl-Heinz Krause +1 more
TL;DR: This review summarizes the current state of knowledge of the functions of NOX enzymes in physiology and pathology.
Journal ArticleDOI
Bone marrow cells regenerate infarcted myocardium
Donald Orlic,Jan Kajstura,Stefano Chimenti,Igor Jakoniuk,Stacie M. Anderson,Baosheng Li,James Pickel,Ronald D.G. McKay,Bernardo Nadal-Ginard,David M. Bodine,Annarosa Leri,Piero Anversa +11 more
TL;DR: It is indicated that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease.
Journal ArticleDOI
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.
TL;DR: It is discovered that display of Hoechst fluorescence simultaneously at two emission wavelengths revealed a small and distinct subset of whole bone marrow cells that had phenotypic markers of multipotential HSC, which were shown in competitive repopulation experiments to contain the vast majority of HSC activity from murine bone marrow and to be enriched at least 1,000-fold for in vivo reconstitution activity.
Journal ArticleDOI
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
Olaia Naveiras,Valentina Nardi,Valentina Nardi,Pamela L. Wenzel,Pamela L. Wenzel,Peter V. Hauschka,Frederic H. Fahey,George Q. Daley,George Q. Daley +8 more
TL;DR: In lipoatrophic A-ZIP/F1 ‘fatless’ mice, and in mice treated with the peroxisome proliferator-activated receptor-γ inhibitor bisphenol A diglycidyl ether, marrow engraftment after irradiation is accelerated relative to wild-type or untreated mice, suggesting that antagonizing marrow adipogenesis may enhance haematopoietic recovery in clinical bone-marrow transplantation.
Related Papers (5)
Diabetes Impairs Hematopoietic Stem Cell Mobilization by Altering Niche Function
Francesca Ferraro,Stefania Lymperi,Simón Méndez-Ferrer,Borja Saez,Joel A. Spencer,Joel A. Spencer,Beow Y. Yeap,Elena Masselli,Gallia Graiani,Lucia Prezioso,Elisa Lodi Rizzini,Marcellina Mangoni,Vittorio Rizzoli,Stephen M. Sykes,Charles P. Lin,Paul S. Frenette,Federico Quaini,David T. Scadden +17 more