S
Stephen J. Jenkins
Researcher at University of Edinburgh
Publications - 61
Citations - 6475
Stephen J. Jenkins is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Macrophage & Inflammation. The author has an hindex of 27, co-authored 54 publications receiving 5263 citations. Previous affiliations of Stephen J. Jenkins include University of York.
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Journal ArticleDOI
Tissue-resident macrophages
TL;DR: The tissue niche-specific factors that dictate cell phenotype are discussed, which will allow new strategies to promote the restoration of tissue homeostasis and explain why simplified models of macrophage activation do not explain the extent of heterogeneity seen in vivo.
Journal ArticleDOI
Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation
Stephen J. Jenkins,Dominik Rückerl,Peter C. Cook,Lucy H. Jones,Fred D. Finkelman,Fred D. Finkelman,Nico van Rooijen,Andrew S. MacDonald,Judith E. Allen +8 more
TL;DR: It is revealed that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in order to increase population density, and expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells.
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Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities
Calum C. Bain,Catherine A. Hawley,Hannah Garner,Charlotte L. Scott,Anika Schridde,Nicholas J. Steers,Matthias Mack,Anagha Joshi,Martin Guilliams,Allan McI. Mowat,Frederic Geissmann,Frederic Geissmann,Stephen J. Jenkins +12 more
TL;DR: Although monocyte-derived F4/80hi macrophages eventually displace the embryonic population with age in a process that is highly gender dependent and not due to proliferative exhaustion of the incumbent embryonic population, despite the greater proliferative activity of newly recruited cells.
Journal ArticleDOI
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1
Stephen J. Jenkins,Dominik Rückerl,Graham D. Thomas,James P. Hewitson,Sheelagh Duncan,Frank Brombacher,Rick M. Maizels,David A. Hume,Judith E. Allen +8 more
TL;DR: IL-4 and CSF-1 both contribute to macrophages proliferation during nematode infection, but IL-4 permits increased tissue macrophage density without the coincident monocyte infiltration associated with elevated CSF1 levels.
Journal ArticleDOI
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation
Luke C. Davies,Marcela Rosas,Stephen J. Jenkins,Chia-Te Liao,Martin J. Scurr,Frank Brombacher,Frank Brombacher,Donald James Fraser,Judith E. Allen,Simon Arnett Jones,Philip R. Taylor +10 more
TL;DR: It is shown that proliferation of both bone marrow-derived inflammatory and tissue resident macrophage lineage branches is a key feature of the inflammatory process with major implications for the mechanisms underlying recovery from inflammation.