S
Stephen J. Smith
Researcher at Allen Institute for Brain Science
Publications - 127
Citations - 22271
Stephen J. Smith is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Postsynaptic potential & Synapse. The author has an hindex of 59, co-authored 118 publications receiving 20466 citations. Previous affiliations of Stephen J. Smith include Stanford University & Yale University.
Papers
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Journal ArticleDOI
Array tomography: rodent brain fixation and embedding.
TL;DR: This protocol describes the fixation and processing required to prepare tissues for immunofluorescence array tomography, which makes it possible to visualize and quantify previously inaccessible features of tissue structure and molecular architecture.
Proceedings ArticleDOI
Low-frequency noise characterization of near-IR VCSELs for functional brain imaging
TL;DR: In this paper, the authors characterized the relative intensity noise (RIN) of commercial VCSEL devices and evaluated their feasibility for use in an integrated semiconductor optical sensor for functional brain imaging using Intrinsic Optical Signals (IOS).
Journal Article
Confocal imaging of mossy fiber growth in live hippocampal slices.
TL;DR: Time-lapse observations were made in area CA3 at a time when mossy fibers are normally growing in and forming en passant synapses with pyramidal neurons, and dynamic filopodia-like structures were found to be associated with axonal varicosities proximal to the leading growth cone.
Journal ArticleDOI
A Computational Synaptic Antibody Characterization Tool for Array Tomography
Anish K. Simhal,Belvin Gong,James S. Trimmer,Richard J. Weinberg,Stephen J. Smith,Guillermo Sapiro,Kristina D. Micheva +6 more
TL;DR: An automated framework for characterization and screening of antibodies against synaptic molecules for high-resolution immunofluorescence array tomography (AT) and an automatic, robust, flexible, and efficient tool for antibody characterization at scale are introduced.