S
Stephen J. Smith
Researcher at Allen Institute for Brain Science
Publications - 127
Citations - 22271
Stephen J. Smith is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Postsynaptic potential & Synapse. The author has an hindex of 59, co-authored 118 publications receiving 20466 citations. Previous affiliations of Stephen J. Smith include Stanford University & Yale University.
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Journal ArticleDOI
Calcium ions, active zones and synaptic transmitter release
TL;DR: Consideration of the spatial and temporal profile of Ca 2+ signals within presynaptic cytoplasm suggests that influx from a number ofCa 2+ channels may contribute to the Ca 2- signal responsible for triggering a vesicular exocytosis event, and that this signal results in a transient elevation of Ca 1+ concentration on the order of 100 μm at sites of secretion.
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Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
Nicola J. Allen,Mariko L. Bennett,Lynette C. Foo,Gordon X. Wang,Chandrani Chakraborty,Stephen J. Smith,Ben A. Barres +6 more
TL;DR: Glypicans is identified as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses.
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The kinetics of synaptic vesicle recycling measured at single presynaptic boutons
Timothy A. Ryan,Harald Reuter,Beverly Wendland,Felix E. Schweizer,Richard W. Tsien,Stephen J. Smith +5 more
TL;DR: It is shown that endocytosis is not dependent on membrane potential and, unlike exocytotic, that it is independent of extracellular Ca2+.
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Neural activity and the dynamics of central nervous system development
TL;DR: Imaging studies show that the iterative formation and elimination of synapses and neuronal branches result in the formation of a much larger number of trial connections than is maintained in the mature brain.
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Diverse migratory pathways in the developing cerebral cortex.
TL;DR: Time-lapse confocal microscopy was used to observe directly the dynamic behaviors of migrating cells in living slices of developing cortex, and the majority of cells migrated along a radial pathway, consistent with the view that cortical neurons migrate along radial glial fibers.