S
Stephen J. Smith
Researcher at Allen Institute for Brain Science
Publications - 127
Citations - 22271
Stephen J. Smith is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Postsynaptic potential & Synapse. The author has an hindex of 59, co-authored 118 publications receiving 20466 citations. Previous affiliations of Stephen J. Smith include Stanford University & Yale University.
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Journal ArticleDOI
Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target.
Takeshi Hiu,Zoya Farzampour,Jeanne T. Paz,Jeanne T. Paz,Eric H Wang,Corrine Badgely,Andrew Olson,Kristina D. Micheva,Gordon X. Wang,Robin Lemmens,Robin Lemmens,Kevin V. Tran,Yasuhiro Nishiyama,Xibin Liang,Scott Hamilton,Nancy A. O'Rourke,Stephen J. Smith,John R. Huguenard,Tonya M. Bliss,Gary K. Steinberg +19 more
TL;DR: An increase in phasic GABA signalling during the repair phase that enhances plasticity-related recovery in mice is revealed, suggesting therapeutic potential.
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Strong effects of subphysiological temperature on the function and plasticity of mammalian presynaptic terminals.
TL;DR: The results show that there are very substantial differences in synaptic vesicle recycling at physiological temperature as opposed to the common, lower experimental temperatures, and that much new experimental work at the higher physiological temperature range will be needed to understand the true parameters of presynaptic functions.
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Single-cell transcriptomic evidence for dense intracortical neuropeptide networks
Stephen J. Smith,Uygar Sümbül,Lucas T. Graybuck,Forrest Collman,Sharmishtaa Seshamani,Rohan Gala,Olga Gliko,Leila Elabbady,Jeremy A. Miller,Trygve E. Bakken,Jean Rossier,Zizhen Yao,Ed Lein,Hongkui Zeng,Bosiljka Tasic,Michael Hawrylycz +15 more
TL;DR: Here, neuron-type-specific patterns of NP gene expression are used to offer specific, testable predictions regarding 37 peptidergic neuromodulatory networks that may play prominent roles in cortical homeostasis and plasticity.
Journal ArticleDOI
Cholesterol--Making or Breaking the Synapse
Ben A. Barres,Stephen J. Smith +1 more
TL;DR: It turns out that, at least in the culture dish, a type of glial cell called an astrocyte produces the molecule cholesterol, which is taken up by neurons and then directs formation of synapses perhaps by regulating vital signaling pathways.
Journal ArticleDOI
Knowing a nascent synapse when you see it.
TL;DR: New experimental techniques are beginning to illuminate the processes involved in synaptogenesis, but much remains to be learned, including simply how to recognize the synapse in its nascent form.