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Stephen J. Smith
Researcher at Allen Institute for Brain Science
Publications - 127
Citations - 22271
Stephen J. Smith is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Postsynaptic potential & Synapse. The author has an hindex of 59, co-authored 118 publications receiving 20466 citations. Previous affiliations of Stephen J. Smith include Stanford University & Yale University.
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Calcium entry and transmitter release at voltage‐clamped nerve terminals of squid.
TL;DR: Consideration of synaptic transmission kinetics suggests that the voltage dependence of Ca channel opening rates can probably explain the difference in transfer curve limbs, and it is likely that the third‐power function accurately reflects synaptic current transfer, rather than interference from some other voltage‐dependent process.
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Ionic Currents in Molluscan Soma
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Evidence from In Vivo Imaging That Synaptogenesis Guides the Growth and Branching of Axonal Arbors by Two Distinct Mechanisms
Martin P. Meyer,Stephen J. Smith +1 more
TL;DR: Observations provide evidence that synaptogenesis guides axon arbor growth by first promoting initial branch extension and second by selective branch stabilization, and the detailed dynamics of branch retraction suggest strongly that nascent synapses can act at branch tips to arrest retraction.
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Early functional neural networks in the developing retina.
Rachel O.L. Wong,Rachel O.L. Wong,A. Chernjavsky,Stephen J. Smith,Carla J. Shatz,Carla J. Shatz +5 more
TL;DR: Initially in development, at a time when the photoreceptors are not yet even present, there are already functionally defined networks within the retina, which are spontaneously active rather than visually driven, and they involve horizontal rather than vertical pathways.
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High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy
Juan Carlos Tapia,Narayanan Kasthuri,Kenneth J. Hayworth,Richard Schalek,Jeff W. Lichtman,Stephen J. Smith,JoAnn Buchanan +6 more
TL;DR: This technique uses osmium impregnation (OTO) to make the samples conductive while heavily staining membranes for segmentation studies to produce clean, highly contrasted TEM and scanning electron microscopy (SEM) samples of insect, fish and mammalian nervous systems.