S
Stephen O'Rahilly
Researcher at University of Cambridge
Publications - 537
Citations - 81904
Stephen O'Rahilly is an academic researcher from University of Cambridge. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 138, co-authored 520 publications receiving 75686 citations. Previous affiliations of Stephen O'Rahilly include Dana Corporation & University of Oxford.
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Journal ArticleDOI
GDF15 mediates the effects of metformin on body weight and energy balance
Anthony P. Coll,Michael Chen,Pranali Taskar,Debra Rimmington,Satish Patel,John Tadross,Irene Cimino,Ming Yang,Paul Welsh,Sam Virtue,Deborah A. Goldspink,Emily L. Miedzybrodzka,Adam R. Konopka,Raul Ruiz Esponda,Jeffrey T.-J. Huang,Y. C. Loraine Tung,Sergio Rodriguez-Cuenca,Rute A. Tomaz,Heather P. Harding,Audrey Melvin,Giles S.H. Yeo,David Preiss,Antonio Vidal-Puig,Ludovic Vallier,K. Sreekumaran Nair,Nicholas J. Wareham,David Ron,Fiona M. Gribble,Frank Reimann,Naveed Sattar,David B. Savage,Bernard B. Allan,Stephen O'Rahilly +32 more
TL;DR: It is shown—in two independent randomized controlled clinical trials—that metformin increases circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15), which has been shown to reduce food intake and lower body weight through a brain-stem-restricted receptor.
Journal ArticleDOI
Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy.
William T. Gibson,I. Sadaf Farooqi,Mary Moreau,Alex M. DePaoli,Elizabeth Lawrence,Stephen O'Rahilly,Rebecca Trussell +6 more
TL;DR: A Canadian child, of Pakistani origin but unrelated to the previously reported subjects, presenting with severe hyperphagia and obesity, who was found to be homozygous for the Delta133G mutation is reported, providing additional support for the role of leptin in the regulation of the human hypothalamic-pituitary-thyroid axis.
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A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism
Adam J. de Smith,Carolin Purmann,Robin G. Walters,Richard J. Ellis,Susan E. Holder,Mieke M. van Haelst,Angela F. Brady,U. L. Fairbrother,Mehul T. Dattani,Julia M. Keogh,Elana Henning,Giles S.H. Yeo,Stephen O'Rahilly,Philippe Froguel,Philippe Froguel,I. Sadaf Farooqi,Alexandra I. F. Blakemore +16 more
TL;DR: Findings provide direct evidence for the role of a particular family of non-coding RNAs, the HBII-85 snoRNA cluster, in human energy homeostasis, growth and reproduction.
Journal ArticleDOI
Leptin Mediates the Increase in Blood Pressure Associated with Obesity
Stephanie E. Simonds,Jack T. Pryor,Eric Ravussin,Frank L. Greenway,Ralph J. DiLeone,Andrew M. Allen,Jaspreet K. Bassi,Joel K. Elmquist,Julia M. Keogh,Elana Henning,Martin G. Myers,Julio Licinio,Russell D. Brown,Pablo J. Enriori,Stephen O'Rahilly,Scott M. Sternson,Kevin L. Grove,David Spanswick,David Spanswick,I. Sadaf Farooqi,Michael A. Cowley +20 more
TL;DR: It is demonstrated that leptin couples changes in weight to changes in BP in mammalian species, and humans with loss-of-function mutations in leptin and the LepR have low BP despite severe obesity.
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Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA
Marjorie J. Lindhurst,Victoria E. R. Parker,Felicity Payne,Julie C. Sapp,Simon A. Rudge,Julie Harris,Alison M. Witkowski,Qifeng Zhang,Matthijs P. Groeneveld,Carol Scott,Allan Daly,Susan M. Huson,Laura L. Tosi,Michael L. Cunningham,Thomas N. Darling,Joseph Geer,Zoran Gucev,V. Reid Sutton,Christos Tziotzios,Adrian K. Dixon,Timothy R. Helliwell,Stephen O'Rahilly,Stephen O'Rahilly,David B. Savage,David B. Savage,Michael J.O. Wakelam,Inês Barroso,Inês Barroso,Leslie G. Biesecker,Robert K. Semple,Robert K. Semple +30 more
TL;DR: The findings characterize a distinct overgrowth syndrome, biochemically demonstrate activation of PI3K signaling and thereby identify a rational therapeutic target.