S
Stephen O'Rahilly
Researcher at University of Cambridge
Publications - 537
Citations - 81904
Stephen O'Rahilly is an academic researcher from University of Cambridge. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 138, co-authored 520 publications receiving 75686 citations. Previous affiliations of Stephen O'Rahilly include Dana Corporation & University of Oxford.
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Journal ArticleDOI
WNT10B mutations in human obesity
Constantinos Christodoulides,Alessandro Scarda,Marnie Granzotto,Gabriella Milan,E. Dalla Nora,Julia M. Keogh,G. De Pergola,H. Stirling,N Pannacciulli,Jaswinder K. Sethi,Giovanni Federspil,Antonio Vidal-Puig,I. S. Farooqi,Stephen O'Rahilly,Roberto Vettor +14 more
TL;DR: While the pedigree analysis in the case of C256Y WNT10B does not provide definitive proof of a causal link of this variant with obesity, the finding of a non-functioning WNT 10B allele in a human family affected by obesity should encourage further study of this gene in other obese populations.
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Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity.
Paul W. Franks,Soren Brage,Jian'an Luan,Ulf Ekelund,Mushtaquar Rahman,I. Sadaf Farooqi,Ian Halsall,Stephen O'Rahilly,Nicholas J. Wareham +8 more
TL;DR: This study used a prospective population-based cohort of 748 middle-aged whites to test the hypothesis that leptin predicts the development of the features of MS independently of obesity.
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The Link Between Nutritional Status and Insulin Sensitivity Is Dependent on the Adipocyte-Specific Peroxisome Proliferator–Activated Receptor-γ2 Isoform
Gema Medina-Gomez,Sam Virtue,Christopher J. Lelliott,Romina Boiani,Mark Campbell,Constantinos Christodoulides,Christophe Perrin,Mercedes Jimenez-Linan,Margaret Blount,John Dixon,Dirk Zahn,Rosemary R. Thresher,Samuel Aparicio,Mark B. L. Carlton,William H. Colledge,Mikko I. Kettunen,Tuulikki Seppänen-Laakso,Jaswinder K. Sethi,Stephen O'Rahilly,Kevin M. Brindle,Saverio Cinti,Matej Orešič,Rémy Burcelin,Antonio Vidal-Puig +23 more
TL;DR: The results indicate that insulin resistance associated with ablation of PPARgamma2 is not the result of lipodystrophy and suggests a specific role for PPAR Gamma2 in maintaining insulin sensitivity independently of its effects on adipogenesis, and raises the intriguing notion that PPARGamma2 may be necessary for the adverse effects of a high-fat diet on carbohydrate metabolism.
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C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis.
Victoria A. Payne,Wo‑Shing Au,Christopher E. Lowe,Shaikh M. Rahman,Jacob E. Friedman,Stephen O'Rahilly,Justin J. Rochford +6 more
TL;DR: In this paper, C/EBPα was shown to be a regulator of SREBP1c expression in maturing adipocytes using shRNA (short hairpin RNA) and ChIP assays.
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A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels
J. Brent Richards,J. Brent Richards,Dawn M. Waterworth,Stephen O'Rahilly,Marie-France Hivert,Ruth J. F. Loos,John R. B. Perry,Toshiko Tanaka,Nicholas J. Timpson,Robert K. Semple,Nicole Soranzo,Nicole Soranzo,Kijoung Song,Nuno Rocha,Elin Grundberg,Josée Dupuis,Jose C. Florez,Jose C. Florez,Claudia Langenberg,Inga Prokopenko,Richa Saxena,Richa Saxena,Robert Sladek,Yurii S. Aulchenko,David M. Evans,Gérard Waeber,Jeanette Erdmann,Mary-Susan Burnett,Naveed Sattar,Joseph M. Devaney,Christina Willenborg,Aroon D. Hingorani,Jaquelin C. M. Witteman,Peter Vollenweider,Beate Glaser,Christian Hengstenberg,Luigi Ferrucci,David Melzer,Klaus Stark,John E. Deanfield,Janina Winogradow,Martina Grassl,Alistair S. Hall,Josephine M. Egan,John R. Thompson,Sally L. Ricketts,Inke R. König,Wibke Reinhard,Scott M. Grundy,H-Erich Wichmann,Phil Barter,Robert W. Mahley,Y. Antero Kesäniemi,Daniel J. Rader,Muredach P. Reilly,Stephen E. Epstein,Alexandre F.R. Stewart,Cornelia M. van Duijn,Heribert Schunkert,Keith Burling,Panos Deloukas,Tomi Pastinen,Nilesh J. Samani,Ruth McPherson,George Davey Smith,Timothy M. Frayling,Nicholas J. Wareham,James B. Meigs,Vincent Mooser,Tim D. Spector +69 more
TL;DR: A novel protein is identified, ARL15, which influences circulating adiponectin levels and may impact upon CHD risk, and several metabolic traits are identified.