S
Stephen O'Rahilly
Researcher at University of Cambridge
Publications - 537
Citations - 81904
Stephen O'Rahilly is an academic researcher from University of Cambridge. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 138, co-authored 520 publications receiving 75686 citations. Previous affiliations of Stephen O'Rahilly include Dana Corporation & University of Oxford.
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Journal ArticleDOI
A Genomewide Scan for Loci Predisposing to Type 2 Diabetes in a U.K. Population (The Diabetes UK Warren 2 Repository): Analysis of 573 Pedigrees Provides Independent Replication of a Susceptibility Locus on Chromosome 1q
Steven Wiltshire,Steven Wiltshire,Andrew T. Hattersley,Graham A. Hitman,Mark Walker,Jonathan C. Levy,Mike Sampson,Stephen O'Rahilly,Timothy M. Frayling,John I. Bell,John I. Bell,G. Mark Lathrop,Amanda J. Bennett,Amanda J. Bennett,Ranjit Dhillon,Christopher Fletcher,C J Groves,Elizabeth C. Jones,Philip Prestwich,Nikol Simecek,Pamidighantam V. Subba Rao,Marie Wishart,Richard Foxon,Simon L. Howell,Damian Smedley,Lon R. Cardon,Stephan Menzel,Mark I. McCarthy +27 more
TL;DR: These data, derived from one of the largest genome scans undertaken in this condition, confirm that individual susceptibility-gene effects for type 2 diabetes are likely to be modest in size and should accelerate positional cloning efforts in these regions of interest.
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Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice
Xavier Prieur,Crystal Y.L. Mok,Vidya Velagapudi,Vanessa Núñez,Lucía Fuentes,David Montaner,Ko Ishikawa,Alberto Camacho,Nuria Barbarroja,Stephen O'Rahilly,Jaswinder K. Sethi,Joaquín Dopazo,Matej Orešič,Mercedes Ricote,Antonio Vidal-Puig +14 more
TL;DR: The data indicate that the M1 ATM polarization in obesity might be a macrophage-specific manifestation of a more general lipotoxic pathogenic mechanism and indicates that strategies to optimize fat deposition and repartitioning toward adipocytes might improve insulin sensitivity by preventing ATM lipotoxicity and M1 polarization.
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Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
Luca A. Lotta,Robert A. Scott,Stephen J. Sharp,Stephen Burgess,Jian'an Luan,Therese Tillin,Amand F. Schmidt,Fumiaki Imamura,Isobel D. Stewart,John R. B. Perry,Luke Marney,Albert Koulman,Edward D. Karoly,Nita G. Forouhi,Rasmus J. O. Sjögren,Erik Näslund,Juleen R. Zierath,Anna Krook,David B. Savage,Julian L. Griffin,Julian L. Griffin,Nishi Chaturvedi,Aroon D. Hingorani,Kay-Tee Khaw,Inês Barroso,Inês Barroso,Mark I. McCarthy,Stephen O'Rahilly,Nicholas J. Wareham,Claudia Langenberg +29 more
TL;DR: Evidence from this large-scale human genetic and metabolomic study is consistent with a causal role of BCAA metabolism in the aetiology of type 2 diabetes.
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Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
Tuomas O. Kilpeläinen,M. Carola Zillikens,Alena Stančáková,Francis M. Finucane,Janina S. Ried,Claudia Langenberg,Weihua Zhang,Jacques S. Beckmann,Jian'an Luan,Liesbeth Vandenput,Unnur Styrkarsdottir,Yanhua Zhou,Albert V. Smith,Jing Hua Zhao,Najaf Amin,Sailaja Vedantam,Sailaja Vedantam,So-Youn Shin,Talin Haritunians,Mao Fu,Mary F. Feitosa,Meena Kumari,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Emmi Tikkanen,Emmi Tikkanen,Massimo Mangino,Caroline Hayward,Ci Song,Alice M. Arnold,Yurii S. Aulchenko,Ben A. Oostra,Harry Campbell,L. Adrienne Cupples,Kathryn Davis,Angela Döring,Gudny Eiriksdottir,Karol Estrada,José Manuel Fernández-Real,Melissa Garcia,Christian Gieger,Nicole L. Glazer,Candace Guiducci,Albert Hofman,Steve E. Humphries,Bo Isomaa,Leonie C. Jacobs,Antti Jula,David Karasik,Magnus Karlsson,Magnus Karlsson,Kay-Tee Khaw,Lauren J. Kim,Mika Kivimäki,Norman Klopp,Brigitte Kühnel,Johanna Kuusisto,Yongmei Liu,Östen Ljunggren,Mattias Lorentzon,Robert Luben,Barbara McKnight,Dan Mellström,Braxton D. Mitchell,Vincent Mooser,José María Moreno,Satu Männistö,Jeffery R. O'Connell,Laura Pascoe,Leena Peltonen,Leena Peltonen,Leena Peltonen,Belén Peral,Markus Perola,Markus Perola,Bruce M. Psaty,Veikko Salomaa,David B. Savage,Robert K. Semple,Tatjana Škarić-Jurić,Gunnar Sigurdsson,Kijoung Song,Tim D. Spector,Ann-Christine Syvänen,Philippa J. Talmud,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,André G. Uitterlinden,Cornelia M. van Duijn,Antonio Vidal-Puig,Sarah H. Wild,Alan F. Wright,Deborah J. Clegg,Eric E. Schadt,Eric E. Schadt,James F. Wilson,Igor Rudan,Igor Rudan,Samuli Ripatti,Samuli Ripatti,Ingrid B. Borecki,Alan R. Shuldiner,Alan R. Shuldiner,Erik Ingelsson,Erik Ingelsson,John-Olov Jansson,Robert C. Kaplan,Vilmundur Gudnason,Tamara B. Harris,Leif Groop,Douglas P. Kiel,Fernando Rivadeneira,Mark Walker,Inês Barroso,Inês Barroso,Peter Vollenweider,Gérard Waeber,John C. Chambers,Jaspal S. Kooner,Nicole Soranzo,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Kari Stefansson,Kari Stefansson,H-Erich Wichmann,Claes Ohlsson,Stephen O'Rahilly,Nicholas J. Wareham,Elizabeth K. Speliotes,Elizabeth K. Speliotes,Caroline S. Fox,Markku Laakso,Ruth J. F. Loos +134 more
TL;DR: In this paper, a meta-analysis of associations between similar to 2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant independent loci in 39,576 individuals.
Journal ArticleDOI
Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study.
Min Gao,Carmen Piernas,Nerys M. Astbury,Julia Hippisley-Cox,Stephen O'Rahilly,Paul Aveyard,Susan A. Jebb +6 more
TL;DR: In this paper, a prospective, community-based, cohort study was conducted to examine the association between obesity and adverse outcomes after infection with SARS-CoV-2, including interactions with demographic and behavioural characteristics, type 2 diabetes, and other health conditions.