S
Stewart MacArthur
Researcher at University of Cambridge
Publications - 15
Citations - 2822
Stewart MacArthur is an academic researcher from University of Cambridge. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 12, co-authored 15 publications receiving 2595 citations. Previous affiliations of Stewart MacArthur include Lawrence Berkeley National Laboratory & University of Nottingham.
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Journal ArticleDOI
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
Charles E. Massie,Andy G. Lynch,Antonio Ramos-Montoya,Joan Boren,Rory Stark,Ladan Fazli,Anne Y. Warren,H Scott,Basetti Madhu,N L Sharma,Helene Bon,Vinny Zecchini,D. Smith,Gina M. DeNicola,Nik Mathews,Michelle Osborne,James Hadfield,Stewart MacArthur,Boris Adryan,Scott K. Lyons,Kevin M. Brindle,John R. Griffiths,Martin E. Gleave,Paul S. Rennie,David E. Neal,Ian G. Mills +25 more
TL;DR: Cal calcium/calmodulin‐dependent protein kinase kinase 2 is highlighted, which it is shown is overexpressed in prostate cancer and regulates cancer cell growth via its unexpected role as a hormone‐dependent modulator of anabolic metabolism.
Journal ArticleDOI
Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm.
Xiao-Yong Li,Stewart MacArthur,Richard Bourgon,David A. Nix,Daniel A. Pollard,Venky N. Iyer,Aaron Hechmer,Lisa Simirenko,Mark Stapleton,Cris L. Luengo Hendriks,Hou Cheng Chu,Nobuo Ogawa,William Inwood,Victor Sementchenko,Amy Beaton,Richard Weiszmann,Susan E. Celniker,David W. Knowles,Thomas R. Gingeras,Terence P. Speed,Michael B. Eisen,Mark D. Biggin +21 more
TL;DR: Surprisingly, for five of the six factors, their recognition sites are not unambiguously more constrained evolutionarily than the immediate flanking DNA, even in more highly bound and presumably functional regions, indicating that comparative DNA sequence analysis is limited in its ability to identify functional transcription factor targets.
Journal ArticleDOI
Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
Stewart MacArthur,Stewart MacArthur,Xiao-Yong Li,Xiao-Yong Li,Jingyi Li,James B. Brown,Hou Cheng Chu,Lucy Zeng,Brandi P Grondona,Aaron Hechmer,Lisa Simirenko,Soile V.E. Keranen,David W. Knowles,Mark Stapleton,Peter J. Bickel,Mark D. Biggin,Michael B. Eisen,Michael B. Eisen +17 more
TL;DR: It is suggested that most animal transcription factors will be found to show a similar broad overlapping pattern of binding in vivo, with specificity achieved by modulating the amount, rather than the identity, of bound factor.
Journal ArticleDOI
The Androgen Receptor Induces a Distinct Transcriptional Program in Castration-Resistant Prostate Cancer in Man
N L Sharma,Charles E. Massie,Antonio Ramos-Montoya,Vincent Zecchini,H Scott,Alastair D. Lamb,Stewart MacArthur,Rory Stark,Anne Y. Warren,Ian G. Mills,David E. Neal +10 more
TL;DR: A 16 gene signature that outperformed a larger in-vitro-derived signature in clinical data sets is identified, showing the importance of persistent AR signaling in CRPC.
Journal ArticleDOI
Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1
Jessica L. L. Robinson,Stewart MacArthur,Caryn S. Ross-Innes,Wayne D. Tilley,David E. Neal,Ian G. Mills,Jason S. Carroll +6 more
TL;DR: Findings show that AR binds and regulates ER cis‐regulatory elements in molecular apocrine tumours, resulting in a transcriptional programme reminiscent of ER‐mediated transcription in luminal breast cancers.