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Stewart Neifert
Researcher at Johns Hopkins University School of Medicine
Publications - 9
Citations - 533
Stewart Neifert is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Parkin & Dopaminergic. The author has an hindex of 5, co-authored 6 publications receiving 325 citations.
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Journal ArticleDOI
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
Yingfei Wang,Ran An,Ran An,George K.E. Umanah,Hyejin Park,Kalyani Nambiar,Stephen M. Eacker,Bong Woo Kim,Lei Bao,Maged M. Harraz,Calvin Chang,Rong Chen,Jennifer E. Wang,Tae In Kam,Jun Seop Jeong,Zhi Xie,Stewart Neifert,Jiang Qian,Shaida A. Andrabi,Seth Blackshaw,Heng Zhu,Hongjun Song,Guo Li Ming,Valina L. Dawson,Ted M. Dawson +24 more
TL;DR: It is discovered that macrophage migration inhibitory factor (MIF) binds AIF and is required for parthanatos, and EndoG does not have an essential role in PARP-dependent chromatinolysis and cell death in mammals.
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PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival
Yunjong Lee,Daniel A. Stevens,Sung Ung Kang,Haisong Jiang,Yun Il Lee,Han Seok Ko,Leslie A. Scarffe,George Essien Umanah,Hojin Kang,Sangwoo Ham,Tae In Kam,Kathleen Allen,Saurav Brahmachari,Jungwoo Wren Kim,Stewart Neifert,Seung Pil Yun,Fabienne C. Fiesel,Wolfdieter Springer,Valina L. Dawson,Joo Ho Shin,Joo Ho Shin,Ted M. Dawson +21 more
TL;DR: A function of PINK1 to direct parkin-PARIS-regulated PGC-1α expression and dopaminergic neuronal survival is uncovered and alleviates PARIS toxicity.
Journal ArticleDOI
Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.
Yulan Xiong,Stewart Neifert,Senthilkumar S. Karuppagounder,Qinfang Liu,Jeannette N. Stankowski,Byoung Dae Lee,Han Seok Ko,Yunjong Lee,Jonathan C. Grima,Xiaobo Mao,Haisong Jiang,Sung Ung Kang,Deborah A. Swing,Lorraine Iacovitti,Lino Tessarollo,Ted M. Dawson,Valina L. Dawson +16 more
TL;DR: It is indicated that LRRK2-induced DA and NE neurodegeneration is kinase-dependent and can occur in a cell-autonomous manner and human tyrosine hydroxylase (TH) promoter-controlled tetracycline-sensitive L RRK2 G2019S (GS) and LRRk2 G 2019S Kinase-dead (GS/DA) transgenic mice indicate this.
Journal ArticleDOI
Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
Nikhil Panicker,T. I. Kam,Hu Wang,Stewart Neifert,Shih Ching Chou,Manoj Kumar,Saurav Brahmachari,Aanishaa Jhaldiyal,Jared T. Hinkle,Fatih Akkentli,Xiaobo Mao,Enquan Xu,Senthilkumar S. Karuppagounder,Eric Hsu,Sung Ung Kang,Olga Pletnikova,Juan C. Troncoso,Valina L. Dawson,Ted M. Dawson +18 more
TL;DR: In this paper , Parkin activation was found to contribute to the assembly of an active NLRP3 inflammasome complex via mitochondrial-derived reactive oxygen species (mitoROS) generation through the accumulation of another parkin ubiquitination substrate, ZNF746/PARIS.
Journal ArticleDOI
Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology
Yulan Xiong,Stewart Neifert,Senthilkumar S. Karuppagounder,Jeannette N. Stankowski,Byoung Dae Lee,Jonathan C. Grima,Guanxing Chen,Han Seok Ko,Yunjong Lee,Debbie Swing,Lino Tessarollo,Ted M. Dawson,Valina L. Dawson +12 more
TL;DR: These mice provide an important new tool to study neurobiological changes associated with the increased kinase activity from the L RRK2 G2019S mutation, which may ultimately lead to a better understanding of not only the physiologic actions of LRRK2, but also potential pathologic actions that underlie LRRk2 GS-associated PD.