Manoj Kumar

TL;DR: It is shown that activated microglia induce A1 astrocytes by secreting Il-1α, TNF and C1q, and that these cytokines together are necessary and sufficient to induce A2 astroCytes, which are abundant in various human neurodegenerative diseases.

TL;DR: It is found that NLY01 is a potent GLP1R agonist with favorable properties that is neuroprotective through the direct prevention of microglia-mediated conversion of astrocytes to an A1 neurotoxic phenotype and should be evaluated in the treatment of Parkinson’s disease and related neurologic disorders characterized by microglial activation.

TL;DR: In this paper, the disks in the array are accessed simultaneously so that at any given instance, different disks are accessing the video or multimedia data for different streams, and access to the disks for reading the continuous media files is scheduled periodically, with the period equal to the back time of the stripes.

TL;DR: It is shown that ribosomal protein s15 is a key pathogenic LRRK2 substrate in Drosophila and human neuron PD models and can be prevented by phosphodeficient T136A s15, revealing a novel mechanism of PD pathogenesis linked to elevated L RRK2 kinase activity and aberrant protein synthesis in vivo.

TL;DR: The GraphBLAS standard as discussed by the authors defines a core set of matrix-based graph operations that can be used to implement a wide class of graph algorithms in a wide range of programming environments.